Napredna pretraga

Pregled bibliografske jedinice broj: 894962

Rutin as neuroprotective agent: from bench to bedside

Budzynska, Barbara; Faggio, Caterina; Kruk- Slomka, Marta; Šamec, Dunja; Nabavi, Seyed Fazel; Sureda, Antoni; Devi, Kasi Pandima; Nabavi, Seyed Mohammad
Rutin as neuroprotective agent: from bench to bedside // Current medicinal chemistry, 26 (2019), 1-11 doi:10.2174/0929867324666171003114154 (međunarodna recenzija, pregledni rad, znanstveni)

Rutin as neuroprotective agent: from bench to bedside

Budzynska, Barbara ; Faggio, Caterina ; Kruk- Slomka, Marta ; Šamec, Dunja ; Nabavi, Seyed Fazel ; Sureda, Antoni ; Devi, Kasi Pandima ; Nabavi, Seyed Mohammad

Current medicinal chemistry (0929-8673) 26 (2019); 1-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Alzheimer's disease ; antioxidant ; flavonoid ; neurodegenerative diseases ; polyphenols ; rutin

Lavonoids are major dietary constituents of plant-based food that occur ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol and consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert divers biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti- inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes is reviewed, as well as their bioavailability and pharmacokinetics, which is essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin are proposed to exert its neuroprotective effects.

Izvorni jezik

Znanstvena područja


Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Dunja Šamec, (312892)

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus