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Distinctiveness of the Roma population within CYP2B6 worldwide variation


Tomas, Željka; Škarić-Jurić, Tatjana; Kuhanec, Antonija; Zajc Petranović, Matea; Smolej Narančić, Nina; Janićijević, Branka; Peričić Salihović, Marijana
Distinctiveness of the Roma population within CYP2B6 worldwide variation // Pharmacogenomics, 18 (2017), 17; 1575-1587 (međunarodna recenzija, članak, znanstveni)


Naslov
Distinctiveness of the Roma population within CYP2B6 worldwide variation

Autori
Tomas, Željka ; Škarić-Jurić, Tatjana ; Kuhanec, Antonija ; Zajc Petranović, Matea ; Smolej Narančić, Nina ; Janićijević, Branka ; Peričić Salihović, Marijana

Izvornik
Pharmacogenomics (1462-2416) 18 (2017), 17; 1575-1587

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CYP2B6 ; ADME ; pharmacogenetics ; isolate ; Gypsy ; anthropology ; Croatia

Sažetak
Aim was to determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) population originating from India and to examine it in the worldwide perspective. Seven SNP loci (rs12721655, rs2279343, rs28399499, rs34097093, rs3745274, rs7260329, rs8192709) were genotyped in 439 subjects using KASP method. The Croatian Roma took an outlying position in CYP2B6 variation from the worldwide perspective mainly due to their exceptionally high MAF for rs8192709 (12.8%), and lower MAF for rs2279343 (21.1%) compared to south Asian populations. This study provides the first data of several CYP2B6 polymorphisms in Roma population and indicates the need for systematic investigation of the most important pharmacogenes' variants in this large, transnationally isolated population worldwide.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

Napomena
Https://www.futuremedicine.com/doi/10.2217/pgs- 2017-0105 ; https://doi.org/10.2217/pgs-2017-0105



POVEZANOST RADA


Projekt / tema
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Branka Janićijević, )
HRZZ-IP-2014-09-4454 - utjecaj podrijetla i izolacije na ADME gene: primjer romske populacije (Marijana Peričić Salihović, )

Ustanove
Institut za antropologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE