engleski

On cluster sizes during lens growth in the mouse

Use of a stochastic lens growth model allows the size of epithelial cell clusters to be calculated as a function of both time and latitudinal position on the lens surface. The distribution of predicted cluster sizes was consistent with results of lineage tracing studies. The pause in CZ growth from three to six months has the effect of skewing the cluster size distribution towards smaller values. We hypothesize that this effect would serve to minimize the likelihood of deleterious somatic mutations flowing from sun-exposed regions of the epithelium into the fiber cell body.

Eye lens ; growth model ; Clusters

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