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Pregled bibliografske jedinice broj: 892266

In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates


Bogdan, Maja; Drenjančević, Domagoj; Harsanji Drenjančević, Ivana; Bedenić, Branka; Zujić Atalić, Vlasta; Talapko, Jasminka; Vuković, Dubravka
In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates // Journal of chemotherapy, 30 (2018), 1; 16-24 doi:10.1080/1120009X.2017.1378835 (međunarodna recenzija, članak, znanstveni)


Naslov
In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates

Autori
Bogdan, Maja ; Drenjančević, Domagoj ; Harsanji Drenjančević, Ivana ; Bedenić, Branka ; Zujić Atalić, Vlasta ; Talapko, Jasminka ; Vuković, Dubravka

Izvornik
Journal of chemotherapy (1120-009X) 30 (2018), 1; 16-24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acinetobacter baumannii ; Biofilm ; Subminimal inhibitory concentration ; Antibiotic ; Virulence factors

Sažetak
The ability of A cinetobacter baumannii strains to form biofilm is one of the most important virulence factor which enables bacterial survival in a harsh environment and decreases antibiotic concentration as well. Subminimal inhibitory concentrations (subMICs) of antibiotics may change bacterial ultrastructure or have an influence on some different molecular mechanisms resulting in morphological or physiological changes in bacteria itself. The aim of this study was to determine effects of 1/2, 1/4, 1/8 and 1/16 minimal inhibitory concentrationsof imipenem, ampicillin- sulbactam, azithromycin, rifampicin and colistin on biofilm formation ability of 22 biofilm non-producing and 46 biofilm producing A. baumannii strains (30 weak producing strains and 16 moderate producing strains). Results of this study indicate that 1/2–1/16 MICs of imipenem, azithromycin, and rifampicin can reduce bacterial biofilm formation ability in moderate producing strains (p < 0.05), whereas 1/16 MIC of imipenem and 1/4–1/8 MICs of rifampicin reduce the biofilm formation in weak producing strains (p < 0.05). Statisticaly significant effect was detected among biofilm non-producing strains after their exposure to 1/16 MIC of azithromycin (p = 0.039). SubMICs of ampicillin-sulbactam and colistin did not have any significant effect on biofilm formation among tested A. baumannii strains.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
VIF2016-MEFOS-27

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Bogdan, Maja; Drenjančević, Domagoj; Harsanji Drenjančević, Ivana; Bedenić, Branka; Zujić Atalić, Vlasta; Talapko, Jasminka; Vuković, Dubravka
In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates // Journal of chemotherapy, 30 (2018), 1; 16-24 doi:10.1080/1120009X.2017.1378835 (međunarodna recenzija, članak, znanstveni)
Bogdan, M., Drenjančević, D., Harsanji Drenjančević, I., Bedenić, B., Zujić Atalić, V., Talapko, J. & Vuković, D. (2018) In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates. Journal of chemotherapy, 30 (1), 16-24 doi:10.1080/1120009X.2017.1378835.
@article{article, year = {2018}, pages = {16-24}, DOI = {10.1080/1120009X.2017.1378835}, keywords = {Acinetobacter baumannii, Biofilm, Subminimal inhibitory concentration, Antibiotic, Virulence factors}, journal = {Journal of chemotherapy}, doi = {10.1080/1120009X.2017.1378835}, volume = {30}, number = {1}, issn = {1120-009X}, title = {In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates}, keyword = {Acinetobacter baumannii, Biofilm, Subminimal inhibitory concentration, Antibiotic, Virulence factors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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