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Pregled bibliografske jedinice broj: 892118

Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes


Franke, Vedran; Ganesh, Sravya; Karlić, Rosa; Malik, Radek; Pasulka, Josef; Horvat, Filip; Kuzman, Maja; Fulka, Helena; Cernohorska, Marketa; Urbanova, Jana et al.
Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes // Genome research, 27 (2017), 8; 1384-1394 doi:10.1101/gr.216150.116 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 892118 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes

Autori
Franke, Vedran ; Ganesh, Sravya ; Karlić, Rosa ; Malik, Radek ; Pasulka, Josef ; Horvat, Filip ; Kuzman, Maja ; Fulka, Helena ; Cernohorska, Marketa ; Urbanova, Jana ; Svobodova, Eliska ; Ma, Jun ; Suzuki, Yutaka ; Aoki, Fugaku ; Schultz, Richard M. ; Vlahoviček, Kristian ; Svoboda, Petr

Izvornik
Genome research (1088-9051) 27 (2017), 8; 1384-1394

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LTR, retrotransposon, oocyte, zygote, lncRNA, gene expression

Sažetak
Retrotransposons are 'copy-and-paste' insertional mutagens that substantially contribute to mammalian genome content. Retrotransposons often carry long terminal repeats (LTRs) for retrovirus-like reverse transcription and integration into the genome. We report an extraordinary impact of a group of LTRs from the mammalian endogenous retrovirus- related ERVL retrotransposon class on gene expression in the germline and beyond. In mouse, we identified >800 LTRs from ORR1, MT, MT2, and MLT families, which resemble mobile gene-remodeling platforms that supply promoters and first exons. The LTR-mediated gene remodeling also extends to hamster, human, and bovine oocytes. The LTRs function in a stage- specific manner during the oocyte-to-embryo transition by activating transcription, altering protein-coding sequences, producing non-coding RNAs, and even supporting evolution of new protein-coding genes. These functions result, for example, in recycling processed pseudogenes into mRNAs or lncRNAs with regulatory roles. The functional potential of the studied LTRs is even higher because we show that dormant LTR promoter activity can rescue loss of an essential upstream promoter. We also report a novel protein-coding gene evolution - D6Ertd527e, where an MT LTR provided a promoter and the 5' exon with a functional start codon while the bulk of the protein-coding sequence evolved through an CAG repeat expansion. Altogether, ERVL LTRs provide molecular mechanisms for stochastically scanning, rewiring, and recycling genetic information on an extraordinary scale. ERVL LTRs thus offer means for a comprehensive survey of genome's expression potential, tightly intertwining with gene expression and evolution in the germline.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)

Avatar Url Vedran Franke (autor)

Avatar Url Maja Kuzman (autor)

Citiraj ovu publikaciju

Franke, Vedran; Ganesh, Sravya; Karlić, Rosa; Malik, Radek; Pasulka, Josef; Horvat, Filip; Kuzman, Maja; Fulka, Helena; Cernohorska, Marketa; Urbanova, Jana et al.
Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes // Genome research, 27 (2017), 8; 1384-1394 doi:10.1101/gr.216150.116 (međunarodna recenzija, članak, znanstveni)
Franke, V., Ganesh, S., Karlić, R., Malik, R., Pasulka, J., Horvat, F., Kuzman, M., Fulka, H., Cernohorska, M. & Urbanova, J. (2017) Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes. Genome research, 27 (8), 1384-1394 doi:10.1101/gr.216150.116.
@article{article, year = {2017}, pages = {1384-1394}, DOI = {10.1101/gr.216150.116}, keywords = {LTR, retrotransposon, oocyte, zygote, lncRNA, gene expression}, journal = {Genome research}, doi = {10.1101/gr.216150.116}, volume = {27}, number = {8}, issn = {1088-9051}, title = {Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes}, keyword = {LTR, retrotransposon, oocyte, zygote, lncRNA, gene expression} }
@article{article, year = {2017}, pages = {1384-1394}, DOI = {10.1101/gr.216150.116}, keywords = {LTR, retrotransposon, oocyte, zygote, lncRNA, gene expression}, journal = {Genome research}, doi = {10.1101/gr.216150.116}, volume = {27}, number = {8}, issn = {1088-9051}, title = {Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes}, keyword = {LTR, retrotransposon, oocyte, zygote, lncRNA, gene expression} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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