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Fate of hydroxychloroquine in the aquatic environment (CROSBI ID 651603)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Babić, Sandra ; Dabić, Dario ; Ćurković, Lidija Fate of hydroxychloroquine in the aquatic environment // Proceedings of the 15th International Conference on Environmental Science and Technology / Lekkas, D.F. (ur.). Atena: Kalliopi Vrentzou, 2017. str. 1-5

Podaci o odgovornosti

Babić, Sandra ; Dabić, Dario ; Ćurković, Lidija

engleski

Fate of hydroxychloroquine in the aquatic environment

Hydroxychloroquine (HCQ) is a drug used to prevent or treat malaria infections and to treat certain autoimmune diseases such as lupus and rheumatoid arthritis. It is a high production volume pharmaceutical and has a potential for being persistent and bioaccumulative. In this work hydrolytic and photolytic stability of hydroxychloroquine was investigated. Hydrolytic stability was examined according to the OECD guideline 111 and preliminary results show that hydroxychloroquine is resistant to hydrolytic degradation. The photolytic degradation of HCQ was investigated under simulated solar radiation in MilliQ water and spring water. The results showed that investigated pharmaceutical degrade very slowly with half-laves of 5.5 h and 11.6 h in spring and MilliQ water, respectively. Effect of pH value on photodegradation rate was examined and results show significantly influence, faster degradation was observed at higher pH value. Obtained half-lives ranged from 23.1 h for pH 4 to 5.5 min for pH 9. Photodegradation followed first order kinetics with coefficients of determination (r2) higher than 0.99. Samples from hydrolytic and photolytic experiments were analyzed using high performance liquid chromatography.

pharmaceuticals ; hydroxychloquine ; hydrolysis ; photolysis

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Podaci o prilogu

1-5.

2017.

objavljeno

Podaci o matičnoj publikaciji

Proceedings of the 15th International Conference on Environmental Science and Technology

Lekkas, D.F.

Atena: Kalliopi Vrentzou

978-960-7475-53-4

1106-5516

Podaci o skupu

15th International Conference on Environmental Science and Technology

poster

31.08.2017-02.09.2017

Atena, Grčka

Povezanost rada

Kemija