Fate of hydroxychloroquine in the aquatic environment (CROSBI ID 651603)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Babić, Sandra ; Dabić, Dario ; Ćurković, Lidija
engleski
Fate of hydroxychloroquine in the aquatic environment
Hydroxychloroquine (HCQ) is a drug used to prevent or treat malaria infections and to treat certain autoimmune diseases such as lupus and rheumatoid arthritis. It is a high production volume pharmaceutical and has a potential for being persistent and bioaccumulative. In this work hydrolytic and photolytic stability of hydroxychloroquine was investigated. Hydrolytic stability was examined according to the OECD guideline 111 and preliminary results show that hydroxychloroquine is resistant to hydrolytic degradation. The photolytic degradation of HCQ was investigated under simulated solar radiation in MilliQ water and spring water. The results showed that investigated pharmaceutical degrade very slowly with half-laves of 5.5 h and 11.6 h in spring and MilliQ water, respectively. Effect of pH value on photodegradation rate was examined and results show significantly influence, faster degradation was observed at higher pH value. Obtained half-lives ranged from 23.1 h for pH 4 to 5.5 min for pH 9. Photodegradation followed first order kinetics with coefficients of determination (r2) higher than 0.99. Samples from hydrolytic and photolytic experiments were analyzed using high performance liquid chromatography.
pharmaceuticals ; hydroxychloquine ; hydrolysis ; photolysis
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Podaci o prilogu
1-5.
2017.
objavljeno
Podaci o matičnoj publikaciji
Proceedings of the 15th International Conference on Environmental Science and Technology
Lekkas, D.F.
Atena: Kalliopi Vrentzou
978-960-7475-53-4
1106-5516
Podaci o skupu
15th International Conference on Environmental Science and Technology
poster
31.08.2017-02.09.2017
Atena, Grčka