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The effect of a short term high salt diet on cerebrovascular reactivity in response to breath holding test in young healthy subjects

Questions: There is a paucity of data on the effect of high salt diet on cerebral vessels dilation mechanisms in response to various stimuli in humans. Present study aimed to evaluate the effect of HS diet on middle cerebral artery (MCA) reactivity to breath holding test (BHT) in healthy human. Methods: Healthy women (N=6) and men (N=5) age 20±1 were included in the study. 3x measurements were performed: 1) before any diet intervention, 2) after 1 week of low salt (LS) diet (< 2, 3g kitchen salt/day) and 3) after 2 week of HS diet (>11, 2 g kitchen salt/day). Transcranial doppler signal (TCD) of the MCA in response to BHT (in duration of 30 seconds) was recorded. Blood pressure was recorded simultaneously by Finopres. Results: Diastolic cerebral blood flow (dCBF) and velocity time integral (VTI) were significantly reduced after HS diet compared to the first measurement. R-R interval, heart rate, systolic cerebral blood flow, cerebral perfusion pressure, cerebral vasomotor reactivity and cerebral pulsatility index did not show statistically significant difference. HS diet did not significantly affect any of arterial blood pressure values. Increased 24h-urinary Na+ excretion after HS diet confirmed that subjects conformed to diet. Conclusions: One week of HS diet can impair the cerebrovascular reactivity in human, even without affecting blood pressure values. Support: University of Osijek research grant, INGI- 2015-16

high salt diet, cerebral blood vessels, breath holding test

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