engleski

Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages

The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1(PAI-1) and methylene tetrahydrofolate reductase (MTHFR)polymorphisms and unexplained spontaneous miscarriages (SM). Materials and Methods: PAI-1 polymorphisms wereevaluated in 150 women with pregnancy in their history.One hundred women with a history of SM formed the studygroup and 50 women with normal pregnancies served as thecontrol group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history compared to 46 women in the control group. For statistical analysis, χ 2 test, Phi, and Cramer V tests were used ; p < 0.05 was taken as a statistically significant result. Results: Our findings show: (a) the correlation between SM and PAI-1 mutations reaches statistical significance ( p = 0.026) ; (b) therewas a statistically significant difference between heterozygous PAI-1 in women with only 1 SM compared to the control group ( p = 0.047) ; (c) the comparison of combinations of both mutations, PAI-1 and MTHFR, with the control group demonstrates statistical significance in favor of women with SM and both mutations ( p = 0.022). Conclusion: PAI-1 and MTHFR polymorphisms may play an important role in pregnancy complications because heterozygous PAI-1 mutations and a combination of both PAI-1 and MTHFR mutationsmight contribute to SM.

Gene polymorphisms · Methylene tetrahydrofolate

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