engleski

Heat shock protein 27 (HSP27/HSPB1) expression is increased in patients with primary and secondary myelofibrosis and may be affecting their survival

Primary myelofibrosis (PMF) is a neoplastic disease originating from clonally transformed pluripotent hematopoietic stem cell. Heat shock proteins (HSP) are expressed by cells in response to different stress stimuli, thus allowing cells to survive in otherwise lethal conditions. Heat shock protein 27 (HSP27) is a small HSP transcribed from heat shock protein family B member 1 (HSPB1) gene. Increased HSP27 expression and phosphorylation were observed in a large number of neoplastic diseases and they have mostly been associated with more aggressive disease features, metastatic behavior, resistance to chemotherapy and poor prognosis. However, these findings are not universal for different malignant diseases and higher HSP27 expression was recognized as a positive marker in some situations. Increased HSP27 expression was also shown to be atheroprotective. In this study, we show the genetic upregulation of HSPB1/HSP27 in myelofibrosis and its potentially favorable impact on survival.

HSP27 ; myelofibrosis ; survival

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