engleski

Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients

Background: The objective of this study was to examine the prognostic significance of carbonic anhydrase IX (CAIX), an endogenous marker for tumor hypoxia ; cellular tumor antigen p53, and apoptosis regulator Bcl-2 in triple-negative breast cancer (TNBC) patients. Methods: Immunohistochemically determined expression of CAIX, p53, Bcl-2 and proliferation factor Ki-67, analyzed on sixty-four paraffin-embedded TNBC tissue samples, was used to assess their relation to clinicopathologic variables and prognostic implication on overall survival (OS). Results: Bcl-2 expression was negatively correlated with histological grade of tumor, while expression of p53 was positively correlated with the same clinical variable (P = 0.036 and P = 0.033, respectively). The p53 expression was also positively correlated with tumor size (P = 0.010). Survival analysis showed that patients with high Bcl-2 expression (above cut-off value determined by ROC curve analysis) have shorter OS (P = 0.020). The same was observed for patients with tumors larger than 5 cm (P = 0.034) or positive lymph nodes (P = 0.004). Among all three examined markers, multivariate analysis showed that only Bcl-2 expression was strong independent prognostic indicator for decreased OS (HR 10.45, 95% CI 2.229–49.022, P = 0.003). Conclusions: Elevated expression of Bcl-2 was an independent prognostic factor for poorer OS in TNBC and as such a significant marker for tumor aggressiveness.

B-cell lymphoma 2 ; carbonic anhydrase IX ; Ki-67 antigen ; triple-negative breast neoplasms ; tumor biomarkers ; tumor suppressor protein p53

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