Microwave-assisted quaternization of various pyridine derivatives and their antibacterial activity (CROSBI ID 241851)
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Podaci o odgovornosti
Bušić, Valentina ; Pavlović, Hrvoje ; Roca, Sunčica ; Vikić-Topić, Dražen ; Gašo-Sokač, Dajana
engleski
Microwave-assisted quaternization of various pyridine derivatives and their antibacterial activity
In this study, reactions of quaternization under microwave heating of pyridine, α- picoline, pyridine-4-aldoxyime, pyridine-2- aldoxime, nicotinamide, isonicotinamide and pyridoxal oxime with different electrophiles: 2-bromo-4'-nitroacetophenone, 2-amino-4- chloromethylthiazole hydrochloride, methyl iodide, 1, 3-diiodopropane and 1, 3- dibromopropane are reported. The synthesis yield by microwave dielectric heating is improved and reaction time shortened compared to conventional heating. The structure of obtained molecules were analyzed and determined by 1D and 2D NMR spectroscopy methods, IR spectroscopy and mass spectrometry. The highest antibacterial activity against two Gram- positive and two Gram-negative bacteria strains has beeen found for 1-[2-(4-nitrophenyl)-2- oxoethyl]pyridinium bromide (2).
microwave synthesis ; pyridine derivatives ; antibacterial activity ; NMR ; quaternization
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