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Pregled bibliografske jedinice broj: 889874

Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia


Vlatković, Suzana; Šagud, Marina; Švob Štrac, Dubravka; Sviben, Mario; Živković, Maja; Vilibić, Maja; Vuksan-Ćusa, Bjanka; Mihaljević-Peleš, Aima; Pivac, Nela
Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia // Schizophrenia research, 193 (2018), 480-481 doi:10.1016/j.schres.2017.08.006 (međunarodna recenzija, pismo uredniku, znanstveni)


CROSBI ID: 889874 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia

Autori
Vlatković, Suzana ; Šagud, Marina ; Švob Štrac, Dubravka ; Sviben, Mario ; Živković, Maja ; Vilibić, Maja ; Vuksan-Ćusa, Bjanka ; Mihaljević-Peleš, Aima ; Pivac, Nela

Izvornik
Schizophrenia research (0920-9964) 193 (2018); 480-481

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
Toxoplasma gondii ; seropositivity ; treatment-resistance ; schizophrenia ; symptom severity

Sažetak
Objective: Patients with schizophrenia have increased prevalence of antibodies against Toxoplasma gondii (TG), whereas TG seropositive patients demonstrate higher symptom severity. The aim of this study was to examine the association of TG seropositivity with treatment-resistant schizophrenia (TRS) and different clinical features. Method: This cross-sectional study included 210 male inpatients with schizophrenia, evaluated by various psychiatric diagnostic rating scales. TG seropositivity was determined by enzyme- linked-fluorescent assay. TRS was defined as a failure of at least 2 adequate antipsychotic trials. Results: TG seropositive patients had twice the rate of treatment-resistance compared to TG seronegative patients. In the TG seropositive group patients were older, lived more often in the countryside, had higher number of previous hospitalizations, longer duration of the disease, as well as increased depressive and suicidal symptoms. Treatment- resistant patients were older, had higher number of previous hospitalizations, longer duration of the disease, increased PANSS total, negative, general psychopathology and cognition scores, depressive symptoms and more suicide attempts during life-time. Conclusion: Our results support the hypothesis that TG seropositivity might contribute to treatment- resistance in schizophrenia, at least in male patients. Our findings also suggest that both treatment-resistant patients as well as TG seropositive patients demonstrate more severe clinical features of schizophrenia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
BM1.45

Ustanove
Hrvatski zavod za javno zdravstvo,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Vlatković, Suzana; Šagud, Marina; Švob Štrac, Dubravka; Sviben, Mario; Živković, Maja; Vilibić, Maja; Vuksan-Ćusa, Bjanka; Mihaljević-Peleš, Aima; Pivac, Nela
Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia // Schizophrenia research, 193 (2018), 480-481 doi:10.1016/j.schres.2017.08.006 (međunarodna recenzija, pismo uredniku, znanstveni)
Vlatković, S., Šagud, M., Švob Štrac, D., Sviben, M., Živković, M., Vilibić, M., Vuksan-Ćusa, B., Mihaljević-Peleš, A. & Pivac, N. (2018) Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia. Schizophrenia research, 193, 480-481 doi:10.1016/j.schres.2017.08.006.
@article{article, year = {2018}, pages = {480-481}, DOI = {10.1016/j.schres.2017.08.006}, keywords = {Toxoplasma gondii, seropositivity, treatment-resistance, schizophrenia, symptom severity}, journal = {Schizophrenia research}, doi = {10.1016/j.schres.2017.08.006}, volume = {193}, issn = {0920-9964}, title = {Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia}, keyword = {Toxoplasma gondii, seropositivity, treatment-resistance, schizophrenia, symptom severity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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