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The effect of intrathecal dexamethasone and levobupivacaine on early postoperative cognitive dysfunction after femur fracture surgery


Šakić, Livija; Tonković, Dinko; Šakicć, Kata; Godan, Borna, Josip
The effect of intrathecal dexamethasone and levobupivacaine on early postoperative cognitive dysfunction after femur fracture surgery // Abstracts and Highlight Papers of the 35th Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress 2016 ; u: Regional anesthesia and pain medicine 41 (2016) (S) e1-e162
XX, XXX, 2015. str. e101-e102 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
The effect of intrathecal dexamethasone and levobupivacaine on early postoperative cognitive dysfunction after femur fracture surgery

Autori
Šakić, Livija ; Tonković, Dinko ; Šakicć, Kata ; Godan, Borna, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts and Highlight Papers of the 35th Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress 2016 ; u: Regional anesthesia and pain medicine 41 (2016) (S) e1-e162 / - , 2015, E101-e102

Skup
Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress (35 ; 2016)

Mjesto i datum
XX, XXX, Xx.-xx.xx.20015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Intratekalna anestezija ; deksametazon ; kognitivna disfunkcija
(Intrathecal anaestehesia ; dexamethasone ; cognitive disfunction)

Sažetak
Cognitive side-effects often complicate postoperative care especially in elderly and fragile patients. The aim of this research is to establish the influence of intrathecal dexamethasone administration in spinal anesthesiawith levobupivacaine on postoperative consciousness and pain for patients with femur fracture. A total of 60 patients ASA2 and ASA3status, scheduled for surgical procedures will be sorted into two groups and undergo surgery. One group will have spinal anesthesia with levobupivacaine, SA group, and the other study group will have spinal anesthesia with addition of dexamethasone, DSA group. Cortisol and glucose are analysed in fivemeasurements. Postoperative cognitive dysfunction is defined by using Confusion Assessment Method (CAM) criteria. Visual analogue scale (VAS) is used to define pain severity. We collected data for 28 patients so far. Data presented as median (minmax) measured variables. Preoperative cortisol levels were713, 25nmol/L, pain intensity( VASscore) 8, 3. Postoperative cortisol plasma levels in 17 patients in DSA group were significantly lower 384(184-511) nmol/L in comparison to 11 patients in SA group with postoperative cortisol plasma levels 551(397-753) nmol/L. The duration of analgesia in DSA group was 428(350-510) minutes and in SA group 212(183-254) minutes. According to CAM criteria, postoperative cognitive disturbanceswere seen in 8 (72%) patients inSA group, and 3 (17%) patients inDSAgroup. The addition of dexamethasone to the local anesthetic has proven so far that it significantly prolongs the duration of sensory block and, thus, decreases opioid requirements and postoperative cognitive disturbances.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE