engleski

Synthesis, Anticancer and Antiviral Activity of Novel 8-(4-Substituted-1H-1, 2, 3-triazol-1- yl)purine Derivatives

Acyclic guanosine analogues are unique class of heterocyclic compounds of interest as agents with proved biologically activity in many cases. The mechanism of their biological activity is based usually on disruption of the metabolic process in which the natural metabolite is an essential part. Thus, phosphorylated into the corresponding 5-O- triphosphates, and incorporated in the growing DNA or RNA chain they terminate virus replication or cancer cell division. Important representative of this class of medicines is acyclovir (ACV), an efficient drug which selectively inhibits DNA replication of the herpes family viruses. Therefore, our research was directed to the synthesis of compounds structurally related to the commercially successful drug acyclovir and screening of the new ACV analogues for antiviral and cytostatic activity.

acyclovir ; purines ; click chemistry ; antiviral ; anticancer

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