engleski

Apolipoprotein E genotypes in relation with Hg, MeHg, As and Se levels in mothers and their newborns

INTRODUCTION: Apolipoprotein E (ApoE, gene APOE) is a lipid binding plasma glycoprotein with central roles in lipid metabolism and neurobiology. Some studies point on its antioxidative, metal-binding and immunomodulatory/anti-inflammatory properties. It has three major isoforms (ApoE2, ApoE3 and ApoE4) encoded by alleles ε2, ε3 and ε4. A large number of studies estimated, that isoform ε4 allele can be associated with different age related disadvantages. Individuals with ε4 variant are supposed to be more susceptible to metal toxicity, including MeHg known to be neurotoxic especially early in life. The purpose of present work was to estimate relations between ApoE polymorphisms and concentrations of selected metal(loid)s (Hg, MeHg, As and Se) in mothers and their newborns, chronically exposed to low or moderate amounts of Hg, mostly through fish consumption during pregnancy.

Apolipoprotein E, genotypes, Hg, MeHg, As and Se levels, mothers and their newborns

nije evidentirano