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Pregled bibliografske jedinice broj: 887214

Transcriptomics and the mechanisms of antidepressant efficacy


Hodgson, K.; Tansey, K.E.; Powell, T.R.; Coppola, G.; Uher, R.; Zvezdana Dernovšek, M.; Mors, O.; Hauser, J.; Souery, D.; Maier, W. et al.
Transcriptomics and the mechanisms of antidepressant efficacy // European neuropsychopharmacology, 26 (2016), 1; 105-112 doi:10.1016/j.euroneuro.2015.10.009 (međunarodna recenzija, članak, znanstveni)


Naslov
Transcriptomics and the mechanisms of antidepressant efficacy

Autori
Hodgson, K. ; Tansey, K.E. ; Powell, T.R. ; Coppola, G. ; Uher, R. ; Zvezdana Dernovšek, M. ; Mors, O. ; Hauser, J. ; Souery, D. ; Maier, W. ; Henigsberg, Neven ; Rietschel, M. ; Placentino, A. ; Aitchison, K.J. ; Craig, I.W. ; Farmer, A.E. ; Breen, G. ; McGuffin, P. ; Dobson, R.

Izvornik
European neuropsychopharmacology (0924-977X) 26 (2016), 1; 105-112

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antidepressants ; Gene expression ; Genetics ; Major Depressive Disorder ; Pharmacogenetics ; Transcriptomics

Sažetak
The mechanisms by which antidepressants have their effects are not clear and the reasons for variability in treatment outcomes are also unknown. However, there is evidence from candidate gene research that indicates gene expression changes may be involved in antidepressant action. In this study, we examined antidepressant-induced alterations in gene expression on a transcriptome-wide scale, exploring associations with treatment response. Blood samples were taken from a subset of depressed patients from the GENDEP study (n=136) before and after eight weeks of treatment with either escitalopram or nortriptyline. Transcriptomic data were obtained from these samples using Illumina HumanHT-12 v4 Expression BeadChip microarrays. When analysing individual genes, we observed that changes in the expression of two genes (MMP28 and KXD1) were associated with better response to nortriptyline. Considering connectivity between genes, we identified modules of genes that were highly coexpressed. In the whole sample, changes in one of the ten identified coexpression modules showed significant correlation with treatment response (cor=0.27, p=0.0029). Using transcriptomic approaches, we have identified gene expression correlates of the therapeutic effects of antidepressants, highlighting possible molecular pathways involved in efficacious antidepressant treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb

Autor s matičnim brojem:
Neven Henigsberg, (200094)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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