engleski

Osteocalcin is associated to metabolic syndrome independent of glycaemic control in postmenopausal women with diabetes type 2

Recent studies in mice and humans demonstrated that low osteocalcin levels are associated with diabetes type 2 and insuline resistance. The objective of this study was to determine the relationship between osteocalcin and glycaemic control versus metabolic syndrome in diabetes type 2 patients. Osteocalcin, HbA1C, insulin, C-peptide, total cholesterol, HDL, LDL and tryglicerides were measured in 66 female postmenopausal patients with diabetes type 2. The patients were divided in 2 groups based on their BMI values: normal 27 and overweight 27 kg/m2. Lower levels of osteocalcin (p0, 017) and HDL (p0, 001) compared to higher levels of insulin (p0, 002), c peptide (p0, 0006) and tryglicerides (p0, 001) were found in the overweight group, while there was no significant differences in HbA1C, cholesterol and LDL levels. Osteocalcin was inversely correlated with waist circumference in all patients while with insulin, c peptide and tryglicerides inverse corellation was observed only in overweight group. HDL was positivley correlated but no correlation was seen with HbA1C. This clearly demonstrates a role of osteocalcin in the pathogenesis of metabolic syndrome independently of glucose metabolism

osteocalcin ; postmenopausal women ; diabetes type 2

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