engleski

Concentrations of the vitamin D metabolite 1, 25(OH)2D and its relationship to inflammatory and metabolic parameters in diabetes type 2

Background: While 25-hydroxy-vitamin D (25(OH)D) has been thoroughly investigated, the role of active vitamin D metabolite 1, 25(OH)2D in a metabolic syndrome still remains unclear. The aim of our study was to determine the association between 25(OH)D and 1, 25(OH)2D levels and several metabolic parameters and inflammatory markers in postmenopausal women with diabetes type 2 (T2DM). Methods: Anthropometric variables, serum 25(OH)D, 1, 25(OH)2D, C-reactive protein (CRP), fibrinogen, PAI-1, fasting glucose, fasting insulin, and HbA1c were measured in 125 postmenopausal women with T2DM. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR) and β-cell function by HOMA-B. A total of 125 diabetic patients were divided by BMI in normal weight group (n=22, BMI 22.7±1.5 kg/m2) and adipose group (n=93, BMI 32.2±5.8 kg/m2). Control group consisted of healthy obese postmenopausal women (n=46, BMI 34.9±6 kg/m2). Results: Serum 25(OH)D concentrations were highest in the lean diabetics compared with obese diabetics and control subjects (P<0.0007) and were significantly associated with fasting glucose, insulin, HOMA-B, BMI, and PAI-1. In diabetic patients 25(OH)D levels were positively associated with HDLC (P<0.01) and negatively with triglycerides (P<0.04) and PAI-1 (P<0.001). Serum 1, 25(OH)2D concentrations were significantly higher in control obese subjects (77.4±17.0 nmol/l) compared with adipose diabetics (P<0.001), with no difference in relation to lean diabetics. Fasting glucose and HbA1c negatively correlated (P<0.01), whereas cholesterol and LDLC positively correlated (P<0.01) with 1, 25(OH)2D. Furthermore, 25(OH)D correlated with PAI-1 in all subjects while 1, 25(OH)2D correlated with fibrinogen but only in obese control subjects. Conclusions: In T2DM women low serum 25(OH)D and 1, 25(OH)2D levels were associated with atherogenic dyslipidemia, glucose parameters, and low grade inflammation. The active hormonal form of vitamin D, 1, 25(OH)2D correlated with cholesterol, LDLC, and fibrinogen, while 25(OH)D correlated with triglycerides, HDLC, and PAI-1, suggesting that there may be an independent mechanism of action for 1, 25(OH)2D in relation to metabolic dysregulation.

vitamin D metabolite 1, 25(OH)2D ; diabetes type 2

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