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Pregled bibliografske jedinice broj: 887043

Bone mineral density in relation to metabolic syndrome components in postmenopausal women with diabetes mellitus type 2


Bilić-Čurčić, Ines; Makarović, Sandra; Mihaljević, Ivan; Franceschi, Maja; Jukić, Tomislav
Bone mineral density in relation to metabolic syndrome components in postmenopausal women with diabetes mellitus type 2 // Acta clinica Croatica, 56 (2017), 58-63 doi:10.20471/acc.2017.56.01.09 (međunarodna recenzija, članak, znanstveni)


Naslov
Bone mineral density in relation to metabolic syndrome components in postmenopausal women with diabetes mellitus type 2

Autori
Bilić-Čurčić, Ines ; Makarović, Sandra ; Mihaljević, Ivan ; Franceschi, Maja ; Jukić, Tomislav

Izvornik
Acta clinica Croatica (0353-9466) 56 (2017); 58-63

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Diabetes mellitus type 2 ; adiposity ; hyperinsulinism ; inflammation ; bone density ; menopause

Sažetak
Diabetes mellitus type 2 is associated with greater bone mineral density (BMD) due to obesity, although rapid bone loss observed over time could be explained by elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinemia, as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type 2 diabetes. Femoral and vertebral BMD, osteocalcin, pyrilinks D, beta-CrossLaps (B- CTx), insulin, C- reactive protein (CRP), fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were measured in 114 postmenopausal female patients with diabetes type 2. The patients of similar age, HbA1c levels and diabetes duration were divided into 2 groups based on their body mass index (BMI) values: lower or equal to 27 kg/m2(31 patients) and higher than 27 kg/m2(83 patients). Lower levels of osteocalcin (p=0.001), B-CTx (p=0.000007) and pyrilinks D (p=0.0365), and higher femoral BMD (p=0.00006), insulin level (p=0.0002), PAI-1 (p=0.00000) and CRP (p=0.002) were found in the overweight group. There were no significant differences in vertebral BMD and fibrinogen. Osteocalcin and B-CTx showed inverse correlation, and femoral BMD positive correlation with waist circumference, insulin level and PAI-1. This suggests that abdominal obesity and hyperinsulinemia as components of the metabolic syndrome could increase femoral BMD by lowering bone rate. In addition, the only inflammation marker linked with femoral BMD was PAI-1, which is associated with increased mineralization of cortical bone in mouse models.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
Akademija medicinskih znanosti,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Science Citation Index-Expanded, Index Medicus, Scopus


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