engleski

Validation of GC/MS method for analysis of methadone in human urine

A fast method for qualitative analysis of methadone inhuman urine using gas chromatography- mass spectrometry (GC-MS) is described. Urine samples were extracted by liquid-liquid extraction using Toxi-tubes A, and were not derivatized. Limit of detection was 25 ng/ml. Method performance in terms of recovery, repeatability and intermediate precision was studied and found to be acceptable for clinical analysis of methadone.

validation, GC/MS, methadone

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