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Pregled bibliografske jedinice broj: 886679

Pathologic patterns of interleukin 10 expression – A review


Trifunović, Jasenka; Miller, Larisa; Debeljak, Željko; Horvat, Vesna
Pathologic patterns of interleukin 10 expression – A review // Biochemia medica, 25 (2015), 1; 36-48 doi:10.11613/BM.2015.004 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Pathologic patterns of interleukin 10 expression – A review

Autori
Trifunović, Jasenka ; Miller, Larisa ; Debeljak, Željko ; Horvat, Vesna

Izvornik
Biochemia medica (1330-0962) 25 (2015), 1; 36-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Autoimmune diseases ; inflammatory diseases ; interleukin 10 ; neoplasms ; polymorphisms, genetic

Sažetak
Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription start site and three single nucleotide polymorphisms (SNPs) -1082(G/A), -819(C/T) and -592(C/A). A large number of studies have shown that IL-10 gene polymorphisms are associated with different diseases and play an important role in pathophysiology and clinical course of these diseases. This review summarizes published literature knowledge about the association of IL-10 polymorphisms and expression patterns with asthma, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, rheumatoid arthritis, tuberculosis and some neoplasms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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