engleski

Novel 1, 2, 3-triazolyl-7-substituted coumarins and bis(coumarin-triazolyl)benzenes: synthesis, photophysical properties and cytostatic evaluation

Coumarins, with the structure of benzopyrone, are widely studied heterocyclic structures in the fields of biology, medicine, perfumes, cosmetics and environmental chemistry. The favourable photophysical properties validated coumarin derivatives as fluorescent probes in cellular imaging and as good chemosensors of some transition metal ions essential for human health. In addition, “click”-derived 1, 2, 3-triazole has become a very common motif from the biological fields to the material sciences. It can interact with biological molecules, organic and inorganic surfaces and materials. Triazole rings have been used as components of fluorogenic probes and as chelating ligands in fluorescent metal sensors. Herein, we report the synthesis, spectroscopic study and cytostatic evaluation of some novel coumarin-triazole conjugated heterocycles as well as 1, 3- and 1, 4-bis(coumarin-triazolyl)benzenes based on Cu(I)-catalyzed azide-alkyne cycloaddition reaction.

coumarins ; click chemistry ; antiproliferative activity

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