engleski

Comparative Molecular Genetic Analysis of the Isolated Bosnian-Herzegovinina and Slovenian Populations

There are local human communities in Selska Valley which are more or less isolated. In this case, isolation have been influenced mostly by geographic and cultural factors. Therefore, the population of Selska Valley is very suitable for molecular- genetics studies of its population structures. Anthropological studies of Selska Valley are performed in 1993 Vidovic (2005) has analyzed a genetic structure of isolated populations which is based on the distribution of the surnames in this area, using Isonomy method as one of the indirect genetic methods. Fifteen autosomal STR loci have been studied in geographically close, but still isolated, populations of villages located in the valley area. The first goal of this study was to identify the possible differences between the populations from two groups of villages: the lowland villages (Bukovica, Sevlje, Dolenja Vas, Selca, Zelezniki and Zali log) and the mountain villages (Podlonk, Prtovc, Spodnje Danje, Zgornja Sorica and Spodnja Sorica). Even though there have been different isolation levels and openness among these villages, in genetic terms they, especially those in the mountain area, may be considered inland islands. The DNA has been obtained from 86 individuals, and the allele frequencies and genetic diversity have been compared among these two sample groups. In addition, all of the fifteen STR loci have been used in a comparative population analysis between the Selska Valley and the Bosnian mountain area. Although the sample sizes are relatively small, the observed variation within any of these small isolated populations is high and comparable to less isolated groups. Even though the populations are geographically isolated, the STR data are similar among the populations. Selska Valley and its village populations certainly represents a distinct isolate, and therefore studies of this type could significantly contribute to a better understanding of the populations and isolates in general.

Short Tandem Repeat (STR), Isolated population, Heterozygosity, Inland Islands, Genetic distance

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