Cytotoxicity assessment of aroylhydrazone derivatives (CROSBI ID 650249)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kontrec, Darko ; Iliev, Ivan ; Detcheva, Roumiana ; Galić, Nives ; Pajpanova, Tamara
engleski
Cytotoxicity assessment of aroylhydrazone derivatives
Aroylhydrazones have been intensively investigated in recent years due to their versatile properties and applications. Many compounds of this type are biologically active as anticancer, antibacterial and antimicrobial agents. In addition, hydrazones as chelating agents were investigated as potential drugs for treatment of iron-overload associated diseases. In the present work, a group of 17 derivatives was studied for cytotoxic activity, as a part of our investigations on aroylhydrazones. The cytotoxic effect of the compounds was tested on non-tumor cells 3T3 and MCF10 and tumor cell lines HepG2, MCF7 and MDA-MB-231. Compound 11 exhibited the highest growth inhibitory effects on cell lines and significantly higher in tumor cell lines than in non-tumor cell lines. Compounds 5, C and E also show significantly higher cytotoxic activity in tumor cell lines than non-tumor cell lines in the experiment. The study makes it possible to assess the interaction between the structure and activity of the compounds and to understand the further development of hydrazones as more potent and selective antineoplastic agents.
aroylhydrazones ; cytotoxicity ; MTT assay
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
53-53.
2017.
objavljeno
Podaci o matičnoj publikaciji
17th International Symposium and Summer School on Bioanalysis : Book of Abstracts
Stafilov, Trajče
Ohrid:
Podaci o skupu
17th International Symposium and Summer School on Bioanalysis,
poster
02.07.2017-08.07.2017
Ohrid, Sjeverna Makedonija