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Falsely elevated serum oestradiol due to exemestane therapy


Mandić, Sanja; Kratzsch, Jutrgen; Mandić, Dario; Debeljak, Željko; Lukuć, Iva; Horvat, Vesna; Gaudl, Alexander; Šerić, Vatroslav
Falsely elevated serum oestradiol due to exemestane therapy // Annals of Clinical Biochemistry, 54 (2017), 3; 402-405 doi:10.1177/0004563216674031 (podatak o recenziji nije dostupan, prikaz, znanstveni)


Naslov
Falsely elevated serum oestradiol due to exemestane therapy

Autori
Mandić, Sanja ; Kratzsch, Jutrgen ; Mandić, Dario ; Debeljak, Željko ; Lukuć, Iva ; Horvat, Vesna ; Gaudl, Alexander ; Šerić, Vatroslav

Izvornik
Annals of Clinical Biochemistry (1758-1001) 54 (2017), 3; 402-405

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
Immunoassay, mass spectrometry, steroid hormones

Sažetak
In this study, we present a case of falsely elevated oestradiol (E2) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry which showed undetectable E2 concentration. The discrepancy is expected to be a consequence of the structural resemblance of E2 and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


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