Falsely elevated serum oestradiol due to exemestane therapy (CROSBI ID 240847)
Prilog u časopisu | prikaz, osvrt, kritika
Podaci o odgovornosti
Mandić, Sanja ; Kratzsch, Jutrgen ; Mandić, Dario ; Debeljak, Željko ; Lukuć, Iva ; Horvat, Vesna ; Gaudl, Alexander ; Šerić, Vatroslav
engleski
Falsely elevated serum oestradiol due to exemestane therapy
In this study, we present a case of falsely elevated oestradiol (E2) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry which showed undetectable E2 concentration. The discrepancy is expected to be a consequence of the structural resemblance of E2 and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy.
Immunoassay ; mass spectrometry ; steroid hormones
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Podaci o izdanju
54 (3)
2017.
402-405
objavljeno
0004-5632
1758-1001
10.1177/0004563216674031
Povezanost rada
Kliničke medicinske znanosti