engleski

Inositol lipids in the cell nucleus

The first evidnece showing involvement of phospholipids in transducing a signal inside the cell came from studies on the cellular plasma membrane. Hokin and Hokin showed involvement of phospholipids in transducing signal through the plasma membrane in 1953. They proved that stimulation of pancreatic cells with acetylcholine leads to incorporation of _3_2P into phosphatidylinositol /PtdIns/, which was the result of stimulating inositide metaobolism. Much later it became clear that this was the result of hydrolyzing inositol lipids in the plasma membrane. In this process there are two phosphorylated compounds produced from PtdIns: first, the phosphatidylinosiotl-4-phosphate /PtdIns(4)P/ is formed by the action of specific kinase on PtdIns and second, the phosphatidylinosiotl-4,5-bisphosphate /PtdIns(4,5)P_2/ is formed by further phsophorylation of of PtdIns(4)P. Diverse extracellular mediators, such as hormones and growth factors, activate the specific phospholipase C which then degrades PtdIns(4,5)P_2.

inositol lipids; cellular plasma membrane; nucleus; phospholipase C; protein kinase C; phosphoinositide-3-kinase; protein kinase B

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