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Pregled bibliografske jedinice broj: 884972

Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study


Kudlek Mikulić, Suzan; Mihaljević Peleš, Alma; Šagud, Marina; Bajs Janović, Maja; Ganoci, Lana; Grubišin, Jasmina; Kuzman Rojnić, Martina; Vuksan Ćusa, Bjanka; Bradaš, Zoran; Božina, Nada
Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study // Nordic journal of psychiatry (2017) (znanstveni, prihvaćen)


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Naslov
Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study

Autori
Kudlek Mikulić, Suzan ; Mihaljević Peleš, Alma ; Šagud, Marina ; Bajs Janović, Maja ; Ganoci, Lana ; Grubišin, Jasmina ; Kuzman Rojnić, Martina ; Vuksan Ćusa, Bjanka ; Bradaš, Zoran ; Božina, Nada

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Nordic journal of psychiatry (2017)

Status rada
Prihvaćen

Ključne riječi
Serum BDNF ; olanzapine ; plasma BDNF ; risperidone ; schizophrenia

Sažetak
Antipsychotics have been the mainstay of the treatment of schizophrenia, and their potential role in neuroprotection could be related to brain-derived neurotrophic factor (BDNF). So far different effects on both serum and plasma levels of BDNF were reported related to the various antipsychotic treatments. Aim of this study was to investigate the influence of olanzapine or risperidone on both plasma and serum levels of BDNF in patients with acute schizophrenia. For 50 participants with acute episode of schizophrenia both plasma and serum BDNF, along with the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression scale, were assessed pretreatment and post treatment - after 6 weeks of either risperidone or olanzapine. Results show that a weak correlation between pretreatment plasma and serum levels of BNDF was found no longer significant after 6 weeks of treatment. Antipsychotics, olanzapine and risperidone showed no significant effect on post treatment plasma and serum levels of BDNF. Pretreatment plasma level of BDNF and PANSS positive subscale were positively correlated. Post treatment serum level of BDNF and Clinical Global Impression were negatively correlated. In conclusion, plasma and serum BDNF levels could be different markers to some extent with regard to clinical symptoms, response to therapy and outcome. The interrelation between serum and plasma BDNF should be established in further studies

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
DOI: 10.1080/08039488.2017.1340518 ; http://dx.doi.org/10.1080/08039488.2017.1340518 ; Online fisrs ; FAQovi 7, 8 i 2 ; 2017-08-17, admin



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Kudlek Mikulić, Suzan; Mihaljević Peleš, Alma; Šagud, Marina; Bajs Janović, Maja; Ganoci, Lana; Grubišin, Jasmina; Kuzman Rojnić, Martina; Vuksan Ćusa, Bjanka; Bradaš, Zoran; Božina, Nada
Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study // Nordic journal of psychiatry (2017) (znanstveni, prihvaćen)
Kudlek Mikulić, S., Mihaljević Peleš, A., Šagud, M., Bajs Janović, M., Ganoci, L., Grubišin, J., Kuzman Rojnić, M., Vuksan Ćusa, B., Bradaš, Z. & Božina, N. (2017) Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study. Prihvaćen za objavljivanje u Nordic journal of psychiatry. [Preprint].
@unknown{unknown, year = {2017}, keywords = {Serum BDNF, olanzapine, plasma BDNF, risperidone, schizophrenia}, journal = {Nordic journal of psychiatry}, title = {Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study}, keyword = {Serum BDNF, olanzapine, plasma BDNF, risperidone, schizophrenia} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
  • Scopus
  • MEDLINE