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Pregled bibliografske jedinice broj: 884307

Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry


Senta, Ivan; Krizman, Ivona; Terzić, Senka; Ahel, Marijan
Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry // Journal of chromatography. A, 1509 (2017), 60-68 doi:10.1016/j.chroma.2017.06.005 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 884307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry

Autori
Senta, Ivan ; Krizman, Ivona ; Terzić, Senka ; Ahel, Marijan

Izvornik
Journal of chromatography. A (0021-9673) 1509 (2017); 60-68

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibiotics ; Azithromycin ; Erythromycin ; Clarithromycin ; Transformation products ; Liquid chromatography–tandem mass spectrometry ; Wastewater ; Surface water

Sažetak
Macrolide antibiotics are a prominent group of emerging contaminants frequently found in wastewater effluents and wastewater-impacted aquatic environments. In this work, a novel analytical method for simultaneous determination of parent macrolide antibiotics (azithromycin, erythromycin, clarithromycin and roxithromycin), along with their synthesis intermediates, byproducts, metabolites and transformation products in wastewater and surface water was developed and validated. Samples were enriched using solid-phase extraction on Oasis HLB cartridges and analyzed by reversed-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry. The target macrolide compounds were separated on an ACE C18 PFP column and detected using multiple reaction monitoring in positive ionization polarity. The optimized method, which included an additional extract clean-up on strong anion-exchange cartridges (SAX), resulted in high recoveries and accuracies, low matrix effects and improved chromatographic separation of the target compounds, even in highly complex matrices, such as raw wastewater. The developed method was applied to the analysis of macrolide compounds in wastewater and river water samples from Croatia. In addition to parent antibiotics, several previously unreported macrolide transformation products and/or synthesis intermediates were detected in municipal wastewater, some of them reaching μg/L levels. Moreover, extremely high concentrations of macrolides up to mg/L level were found in pharmaceutical industry effluents, indicating possible importance of this source to the total loads into ambient waters. The results revealed a significant contribution of synthesis intermediates and transformation products to the overall mass balance of macrolides in the aquatic environment.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-7031 - Sveoubuhvatna procjena ponašanja i sudbine farmaceutski aktivnih tvari u okolišu: makrolidni antibiotici i opioidni analgetici (COMPASS) (Terzić, Senka, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijan Ahel (autor)

Avatar Url Ivona Krizman Matasić (autor)

Avatar Url Senka Terzić (autor)

Avatar Url Ivan Senta (autor)

Citiraj ovu publikaciju

Senta, Ivan; Krizman, Ivona; Terzić, Senka; Ahel, Marijan
Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry // Journal of chromatography. A, 1509 (2017), 60-68 doi:10.1016/j.chroma.2017.06.005 (međunarodna recenzija, članak, znanstveni)
Senta, I., Krizman, I., Terzić, S. & Ahel, M. (2017) Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry. Journal of chromatography. A, 1509, 60-68 doi:10.1016/j.chroma.2017.06.005.
@article{article, year = {2017}, pages = {60-68}, DOI = {10.1016/j.chroma.2017.06.005}, keywords = {Antibiotics, Azithromycin, Erythromycin, Clarithromycin, Transformation products, Liquid chromatography–tandem mass spectrometry, Wastewater, Surface water}, journal = {Journal of chromatography. A}, doi = {10.1016/j.chroma.2017.06.005}, volume = {1509}, issn = {0021-9673}, title = {Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry}, keyword = {Antibiotics, Azithromycin, Erythromycin, Clarithromycin, Transformation products, Liquid chromatography–tandem mass spectrometry, Wastewater, Surface water} }
@article{article, year = {2017}, pages = {60-68}, DOI = {10.1016/j.chroma.2017.06.005}, keywords = {Antibiotics, Azithromycin, Erythromycin, Clarithromycin, Transformation products, Liquid chromatography–tandem mass spectrometry, Wastewater, Surface water}, journal = {Journal of chromatography. A}, doi = {10.1016/j.chroma.2017.06.005}, volume = {1509}, issn = {0021-9673}, title = {Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry}, keyword = {Antibiotics, Azithromycin, Erythromycin, Clarithromycin, Transformation products, Liquid chromatography–tandem mass spectrometry, Wastewater, Surface water} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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