Antiproliferative activity of quinone methides with bodipy chromophore (CROSBI ID 649912)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Cindrić, Matej ; Mlinarić-Majerski, Kata ; Basarić, Nikola ; Martin Kleiner, Irena ; Uzelac, Lidija ; Kralj, Marijeta
engleski
Antiproliferative activity of quinone methides with bodipy chromophore
BODIPY is a trade name for the well known fluorescent dyes comprising different 4, 4-Difluoro-4-bora-3a, 4a-diaza-s-indacene derivatives.[1] These chromophores absorb in the visible region of spectrum and have excellent photophysical and spectral properties characterized by sharp fluorescence peaks with high fluorescence quantum yields.[2] Small modifications of molecular structure lead to fine-tuning of their spectroscopic and photophysical properties.[3] Therefore, a large number of different BODIPY derivatives has been synthesized and their spectroscopic properties have been investigated. We have become interested in the photochemistry of appropriately substituted phenols that undergo photodehydration and deliver quinone methides (QMs) [4]. The interest in the chemistry of QMs has been initiated due to their biological properties. It has been demonstrated that QMs react with amino acids, proteins, nucleotides and DNA. Moreover, ability of QMs to cross-link DNA has been associated to biological action of some anticancer antibiotics such as mitomycin C. Consequently, QMs represent potential new class of anticancer drugs. However, QMs are reactive intermediates that cannot be stored, they have to be generated in situ. The best method for the generation of QMs is photodehydration of phenol derivatives. To have molecules applicable as drugs in human medicine it is of pivotal importance to make QM precursors on the chromophoric system absorbing in the visible part of the spectrum (at > 600 nm) to assure penetration of light through tissue. Herein we present synthesis of QM precursors that bear BODIPY chromophore, investigation of their photochemical reactivity and aptitude to deliver QMs, as well as antiproliferative activity of photogenerated QMs. To test the effect of irradiation, the antiproliferative activity is tested on human cancer cell lines that are treated with compounds and kept in dark or irradiated with visible light.
BODIPY ; quinone methide ; photodeamination ; antiproliferative activity
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Podaci o prilogu
97-97.
2017.
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objavljeno
978-953-55232-8-4
Podaci o matičnoj publikaciji
10th Joint Meeting on Medical Chemistry : Book of Abstracts
Basarić, Nikola ; Namjesnik, Danijel ; Perković, Ivana ; Stepanić, Višnja
Zagreb: Hrvatsko kemijsko društvo
Podaci o skupu
10th Joint Meeting of Medicinal Chemistry
poster
25.06.2017-28.06.2017
Dubrovnik, Hrvatska