engleski

Minimal Helix in the Ferrocene Peptide

We have recently demonstrated that introduction of minimal peptide sequence on aminoferrocene may induce the formation of a β-turn-like structures in solution as well as in the solid state of the derived Boc-(AA)2-NH-Fc peptides. As a continuation of the previous work, we have synthesized higher analogues of these bioconjugates with a potential to form minimum sized peptide helices. Herein, we present the extensive study of conformational preferences of Boc-D-Pro-L-Pro-L-Ala-NH-Fc using NMR-, IR- and CD-spectroscopy, X-ray diffraction and DFT calculations. Results obtained from various techniques indicate that dominant conformation of I is stabilized by two intramolecular hydrogen bonds and ordered in a helical manner in solution as well as in the solid state.

Ferrocene ; Peptide ; Conformational Analysis

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