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Characterization of Silver(I) Complexes with Halo- Substituted Derivatives of Pyridine

The coordination chemistry of silver(I) complexes is very active research area, since these compounds possess antimicrobial and antitumor properties. The well known flexibility of the coordination sphere of the silver atom as well as different role/assistance of the nitrate ion (bridging, monodentate, bidentate ligand) provide the possibility of forming different structured compounds. The halogen atoms (Cl, Br, I) substituted on the pyridine ring (the basic scaffold for many biologically active substances), moderate compounds properties and behavior through halogen and hydrogen bonding. All this together gives rise to design structure property relationships. Presentation shows structural analysis and antibacterial activity results obtained for new AgNO3 complexes with halopyridine ligand of the general formula [Ag(NO3)(Xpy)2] and [Ag(NO3) (X2py)2]. The isolated products were characterized by means of mass spectrometry, multinuclear NMR spectroscopy (1H, 13C, 15N, 109Ag) in solution and by X-ray diffraction data on single crystal.

Antibacterial activity ; Halogen derivatives of pyridine ; NMR spectroscopy ; Silver(I) ; X-ray diffraction

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