engleski

Anaesthetic implications of anticancer chemotherapy

In anaesthetic practice we deal with cancer patients who are scheduled for operations on tumours or other manifestations of malignant disease. Those patients are often debilitated and have significant weight loss accompanied with hypoproteinemia, anaemia and coagulation disorders. Oncological patients usually present to the anaesthetist before tumour disease surgery, but they are also candidates for elective operations (e.g. hernia repair) and urgent/emergency surgery, e.g. trauma, fractuers and ileus. Chemotherapeutic agents given to these patients are potentially noxious, can affect the conduct af anaesthesia and furthermore may aggravate the patoient's condition. In this review the most commonly used cytostatic drug regimens and their common side-effects are listed. Some preclinical studies on anaesthetic and cytostatic drug metabolism and interactions are emphasised, as well as clinically relevant perioperative alterations that may affect anaesthetic management in cancer patients.

antineoplastic agents; anaesthetics; general; antineoplastic combined chemotherapy protocols; combined modality therapy; drug interactions

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