engleski

Synthesis and antioxidative activity of some quaternary 3-hydroxyquinuclidinium salts determined by DPPH method

Antioxidants play an important role as health protecting factors. Scientific evidence suggests that antioxidants reduce the risk for chronic diseases including cancer and heart disease. Primary sources of naturally occurring antioxidants are whole grains, fruits and vegetables. Plant sourced antioxidants like vitamin C, vitamin E, carotenes, phenolic acids etc. have been recognized as agents having the potential to reduce the risk for disease development. Most antioxidants from a typical diet are derived from the plant sources and belong to various classes of chemical compounds with a wide variety of physical and chemical properties. However, recent studies have shown that some synthetic organic compounds could also exhibit a strong antioxidative potential with a possible application in food and pharmaceutical industries. In this study, we have synthesized the quaternary 3- hydroxyquinuclidinium salts bearing different long alkyl chains (C8, C10, C12 and C14). All compounds were obtained in very good yields and characterized. A rapid, simple and inexpensive method to measure antioxidant capacity involving the free radical, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) was utilized in order to test the ability of the synthesized compounds to act as free radical scavengers or hydrogen donors and to evaluate their antioxidant activity. Our preliminary results suggest that the compounds displaying the higher antioxidative activities are those with the longer alkyl chains. Evaluation of the biological potential including the DNA protecting ability of the newly synthesized compounds is currently underway.

quaternary ammonium salts, antioxidation, quinuclidine

nije evidentirano