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Pregled bibliografske jedinice broj: 882308

Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke?


Čeri, Andrea; Coen Herak, Desiree; Leniček Krleža, Jasna; Radić Antolic, Margareta; Horvat, Ivana; Đuranović, Vlasta; Barišić, Nina; Zadro, Renata
Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke? // 12th European Paediatric Neurology Society Congress (EPNS 2017) : abstracts ; u: European Journal of Paediatric Neurology 21 (2017) (S1)
Lyon, Francuska: Elsevier, 2017. str. e161-e162 doi:10.1016/j.ejpn.2017.04.1199 (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 882308 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke?

Autori
Čeri, Andrea ; Coen Herak, Desiree ; Leniček Krleža, Jasna ; Radić Antolic, Margareta ; Horvat, Ivana ; Đuranović, Vlasta ; Barišić, Nina ; Zadro, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th European Paediatric Neurology Society Congress (EPNS 2017) : abstracts ; u: European Journal of Paediatric Neurology 21 (2017) (S1) / - : Elsevier, 2017, E161-e162

Skup
European Paediatric Neurology Society Congress (12 ; 2017)

Mjesto i datum
Lyon, Francuska, 20.-24.06.2017

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pediatric, stroke, localization, thrombophilia, polymorphisms

Sažetak
Pediatric arterial ischemic stroke (AIS) is a relatively rare disorder with multifactorial etiology. A variety of incompletely investigated genetic polymorphisms may cause hypercoagulability and lead to ischemic lesion formation in different parts of brain. As correlation between neuroimaging finding and genetic risk factors might be helpful for further therapeutic decisions, we investigated the significance of inherited prothrombotic gene polymorphisms in different pediatric AIS subtypes according to time of onset and lesion location. Eleven polymorphisms (FV Leiden, FV HR2, FII G20210A, β-fibrinogen −455G>A, FXIII-A Val34Leu, PAI-1 4G/5G, HPA-1, MTHFR C677T, MTHFR A1298C, ACE I/D, apoE ε2-4) were genotyped using a multilocus CVD Strip assay (ViennaLab, Austria) in DNA extracted from blood samples of 112 children (46 girls, 66 boys) with perinatal (N = 51) and childhood AIS (N = 61), and 110 sex- and age-matched controls. FV Leiden (OR: 4.24 ; 95% CI: 1.16–15.46, p = 0.015) and ACE I/D (OR: 1.90 ; 95% CI: 1.01–3.55, p = 0.044) were found to be associated with AIS. Stroke localization data collected from patient medical records and magnetic resonance imaging results indicated cortical stroke in 69 children (39 with perinatal ; 30 with childhood AIS) and subcortical stroke in 43 children, being more frequent in childhood (N = 31), compared to perinatal AIS (N = 12). Cortical and subcortical strokes differed in β- fibrinogen −455G>A genotype distributions (p = 0.026), −455AA genotype was identified in cortical stroke only. Difference in PAI-1 4G/5G genotype distributions was found between childhood and perinatal subcortical stroke (p = 0.028), yielding to a 4.80-fold increased risk for childhood subcortical stroke (95% CI: 1.16– 19.92). Obtained results corroborate previously reported FV Leiden association with AIS (Coen Herak et al. Clin Appl Thromb/Hemost, in press) with additional ACE I/D association. Exclusive associations of β-fibrinogen −455AA genotype with cortical stroke and PAI-1 4G/5G with childhood subcortical stroke support the assumption that specific polymorphisms may contribute to location dependant lesion formation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-2047 - Genski polimorfizmi i ishemijski moždani udar u djece (GENESTROKE) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

doi doi.org www.ejpn-journal.com

Citiraj ovu publikaciju:

Čeri, Andrea; Coen Herak, Desiree; Leniček Krleža, Jasna; Radić Antolic, Margareta; Horvat, Ivana; Đuranović, Vlasta; Barišić, Nina; Zadro, Renata
Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke? // 12th European Paediatric Neurology Society Congress (EPNS 2017) : abstracts ; u: European Journal of Paediatric Neurology 21 (2017) (S1)
Lyon, Francuska: Elsevier, 2017. str. e161-e162 doi:10.1016/j.ejpn.2017.04.1199 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Čeri, A., Coen Herak, D., Leniček Krleža, J., Radić Antolic, M., Horvat, I., Đuranović, V., Barišić, N. & Zadro, R. (2017) Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke?. U: 12th European Paediatric Neurology Society Congress (EPNS 2017) : abstracts ; u: European Journal of Paediatric Neurology 21 (2017) (S1) doi:10.1016/j.ejpn.2017.04.1199.
@article{article, author = {\v{C}eri, Andrea and Coen Herak, Desiree and Leni\v{c}ek Krle\v{z}a, Jasna and Radi\'{c} Antolic, Margareta and Horvat, Ivana and \DJuranovi\'{c}, Vlasta and Bari\v{s}i\'{c}, Nina and Zadro, Renata}, year = {2017}, pages = {e161-e162}, DOI = {10.1016/j.ejpn.2017.04.1199}, keywords = {pediatric, stroke, localization, thrombophilia, polymorphisms}, doi = {10.1016/j.ejpn.2017.04.1199}, title = {Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke?}, keyword = {pediatric, stroke, localization, thrombophilia, polymorphisms}, publisher = {Elsevier}, publisherplace = {Lyon, Francuska} }
@article{article, author = {\v{C}eri, Andrea and Coen Herak, Desiree and Leni\v{c}ek Krle\v{z}a, Jasna and Radi\'{c} Antolic, Margareta and Horvat, Ivana and \DJuranovi\'{c}, Vlasta and Bari\v{s}i\'{c}, Nina and Zadro, Renata}, year = {2017}, pages = {e161-e162}, DOI = {10.1016/j.ejpn.2017.04.1199}, keywords = {pediatric, stroke, localization, thrombophilia, polymorphisms}, doi = {10.1016/j.ejpn.2017.04.1199}, title = {Are inherited prothrombotic gene polymorphisms associated with lesion location in pediatric arterial ischemic stroke?}, keyword = {pediatric, stroke, localization, thrombophilia, polymorphisms}, publisher = {Elsevier}, publisherplace = {Lyon, Francuska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


Citati:





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