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Pregled bibliografske jedinice broj: 882222

An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population


Nadalin, Sergej; Buretić-Tomljanović, Alena
An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population // Prostaglandins leukotrienes and essential fatty acids, 121 (2017), 57-59 doi:10.1016/j.plefa.2017.06.003 (međunarodna recenzija, članak, znanstveni)


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Naslov
An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population

Autori
Nadalin, Sergej ; Buretić-Tomljanović, Alena

Izvornik
Prostaglandins leukotrienes and essential fatty acids (0952-3278) 121 (2017); 57-59

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
age of onset ; PLA2G4C gene polymorphism ; PLA2G6 gene polymorphism ; Positive and Negative Syndrome Scale ; schizophrenia.

Sažetak
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population. We hypothesized that these polymorphic variations might influence the age of schizophrenia onset and Positive and Negative Syndrome Scale psychopathology (PANSS) data. We detected a significant overrepresentation of the PLA2G6-CT and PLA2G4C-AT genotype combination in patients compared with controls (14.7% vs. 7.3%, P < 0.05). The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. We found no significant influence of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity ; whereas, the PLA2G6/PLA2G4C interaction contributed to a similar extent to total PANSS symptom variations.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Nadalin, Sergej; Buretić-Tomljanović, Alena
An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population // Prostaglandins leukotrienes and essential fatty acids, 121 (2017), 57-59 doi:10.1016/j.plefa.2017.06.003 (međunarodna recenzija, članak, znanstveni)
Nadalin, S. & Buretić-Tomljanović, A. (2017) An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. Prostaglandins leukotrienes and essential fatty acids, 121, 57-59 doi:10.1016/j.plefa.2017.06.003.
@article{article, year = {2017}, pages = {57-59}, DOI = {10.1016/j.plefa.2017.06.003}, keywords = {age of onset, PLA2G4C gene polymorphism, PLA2G6 gene polymorphism, Positive and Negative Syndrome Scale, schizophrenia.}, journal = {Prostaglandins leukotrienes and essential fatty acids}, doi = {10.1016/j.plefa.2017.06.003}, volume = {121}, issn = {0952-3278}, title = {An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population}, keyword = {age of onset, PLA2G4C gene polymorphism, PLA2G6 gene polymorphism, Positive and Negative Syndrome Scale, schizophrenia.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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