engleski

The comparative pathology study of feline and canine mammary tumors p53 and p63 immunohistochemical expression

Mammary tumors are common canine and feline neoplastic pathology. The prognosis varies significantly according to the tumor invasion degree. Since myoepithelial layer destruction is considered a differential diagnosis parameter of in situ from invasive lesions in human breast cancer we aimed to explore and evaluate the immunohistochemical expression of p63, a protein specifically expressed by myoepithelial cells of mammary gland. Furthermore its correlation with p53 expression was analyzed. The TP53 gene has the properties as a tumor suppressor gene and is the most frequently affected site of genetic alterations in human malignancies. It encodes the p53 protein in control of expression of a variety of genes involved in cell cycle regulation.

pathology ; immunohistochemistry ; expression ; dog ; cat ; mammary gland

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