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Targeting Notch Signaling Pathway in Malignant Glioma by Inhibiting Mastermind-like (MAML) Transcriptional Function


Opacak-Bernardi, Teuta; Miele, Lucio; Raucher, Drazen
Targeting Notch Signaling Pathway in Malignant Glioma by Inhibiting Mastermind-like (MAML) Transcriptional Function // Annual Mississippi Biophysical Consortium Meeting
Oxford, Mississippi, SAD, 2011. (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Targeting Notch Signaling Pathway in Malignant Glioma by Inhibiting Mastermind-like (MAML) Transcriptional Function

Autori
Opacak-Bernardi, Teuta ; Miele, Lucio ; Raucher, Drazen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Annual Mississippi Biophysical Consortium Meeting

Mjesto i datum
Oxford, Mississippi, SAD, 2. i 3.6.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MAML, elastin-like polypeptide, Notch, glioma

Sažetak
ELP delivery system can be used to target specific proteins in tumors. Notch signaling is compromised in glioma and using an inhibitor linked to ELP can change glioma cells growth and gene expression of target genes. Addition of a cell penetrating peptide to the complex facilitates uptake in the cell.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Osijek