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Pregled bibliografske jedinice broj: 881602

TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.


Perić, Matea; Lovrić, Anita; Šarić, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolić, Andrea; Sobočanec, Sandra; Mikecin, Ana-Matea; Dennerlein, Sven et al.
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. // Aging cell, 16 (2017), 5; 994-1005 doi:10.1111/acel.12623 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 881602 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.

Autori
Perić, Matea ; Lovrić, Anita ; Šarić, Ana ; Musa, Marina ; Bou Dib, Peter ; Rudan, Marina ; Nikolić, Andrea ; Sobočanec, Sandra ; Mikecin, Ana-Matea ; Dennerlein, Sven ; Milošević, Ira ; Vlahoviček, Kristian ; Raimundo, Nuno ; Kriško, Anita

Izvornik
Aging cell (1474-9718) 16 (2017), 5; 994-1005

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ageing ; glucose starvation ; mitochondria ; proteinchaperones ; replicative lifespan ; Snf1/AMPK ; TORC1 ; yeast.

Sažetak
Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein production and maintenance. However, the existence of communication between proteostasis and metabolic networks and its underlying mechanisms remain elusive. Here, we report that enhanced chaperone activity and consequent improved proteostasis are sensed by TORC1 via the activity of Hsp82. Chaperone enrichment decreases the level of Hsp82, which deactivates TORC1 and leads to activation of Snf1/AMPK, regardless of glucose availability. This mechanism culminates in the extension of yeast replicative lifespan (RLS) that is fully reliant on both TORC1 deactivation and Snf1/AMPK activation. Specifically, we identify oxygen consumption increase as the downstream effect of Snf1 activation responsible for the entire RLS extension. Our results set a novel paradigm for the role of proteostasis in aging: modulation of the misfolded protein level can affect cellular metabolic features as well as mitochondrial activity and consequently modify lifespan. The described mechanism is expected to open new avenues for research of aging and age-related diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Mediteranski institut za istraživanje života

Citiraj ovu publikaciju

Perić, Matea; Lovrić, Anita; Šarić, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolić, Andrea; Sobočanec, Sandra; Mikecin, Ana-Matea; Dennerlein, Sven et al.
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. // Aging cell, 16 (2017), 5; 994-1005 doi:10.1111/acel.12623 (međunarodna recenzija, članak, znanstveni)
Perić, M., Lovrić, A., Šarić, A., Musa, M., Bou Dib, P., Rudan, M., Nikolić, A., Sobočanec, S., Mikecin, A. & Dennerlein, S. (2017) TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.. Aging cell, 16 (5), 994-1005 doi:10.1111/acel.12623.
@article{article, year = {2017}, pages = {994-1005}, DOI = {10.1111/acel.12623}, keywords = {ageing, glucose starvation, mitochondria, proteinchaperones, replicative lifespan, Snf1/AMPK, TORC1, yeast.}, journal = {Aging cell}, doi = {10.1111/acel.12623}, volume = {16}, number = {5}, issn = {1474-9718}, title = {TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.}, keyword = {ageing, glucose starvation, mitochondria, proteinchaperones, replicative lifespan, Snf1/AMPK, TORC1, yeast.} }
@article{article, year = {2017}, pages = {994-1005}, DOI = {10.1111/acel.12623}, keywords = {ageing, glucose starvation, mitochondria, proteinchaperones, replicative lifespan, Snf1/AMPK, TORC1, yeast.}, journal = {Aging cell}, doi = {10.1111/acel.12623}, volume = {16}, number = {5}, issn = {1474-9718}, title = {TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.}, keyword = {ageing, glucose starvation, mitochondria, proteinchaperones, replicative lifespan, Snf1/AMPK, TORC1, yeast.} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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