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Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.


Hirche, C.; Frenz, T.; Haas, S.F.; Döring, M.; Borst, K..; Tegtmeyer, .P.K; Brizić, Ilija; Jordan, S.; Keyser, K.; Chhatbar, C. et al.
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. // Cell Reports, 19 (2017), 2345-2356 doi:10.1016/j.celrep.2017.05.063 (međunarodna recenzija, članak, znanstveni)


Naslov
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Autori
Hirche, C. ; Frenz, T. ; Haas, S.F. ; Döring, M. ; Borst, K.. ; Tegtmeyer, .P.K ; Brizić, Ilija ; Jordan, S. ; Keyser, K. ; Chhatbar, C. ; Pronk, E. ; Lin, S. ; Messerle, M. ; Jonjić, Stipan ; Falk, C.S. ; Trumpp, A. ; Essers, M.A.G. ; Kalinke, U.

Izvornik
Cell Reports (2211-1247) 19 (2017); 2345-2356

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Long-term hematopoietic stem cell ; LT-HSC ; quiescence ; type I interferon ; IFN-I ; bone marrow ; virus infection ; vesicular stomatitis virus ; murine cytomegalovirus ; acute infection ; persistent infection ; bone marrow transplantation ; functional

Sažetak
Quiescent long-term hematopoietic stem cells (LTHSCs)are efficiently activated by type I interferon(IFN-I). However, this effect remains poorly investigatedin the context of IFN-I- inducing virus infections.Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long- lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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