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Pregled bibliografske jedinice broj: 881330

Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives


Racané, Livio; Cindrić, Maja; Perin, Nataša; Roškarić, Petra; Starčević, Kristina; Mašek, Tomislav; Maurić, Maja; Dogan, Jasna; Karminski-Zamola, Grace
Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives // Croatica chemica acta, 90 (2017), 2; 187-195 (podatak o recenziji nije dostupan, članak, znanstveni)


Naslov
Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives

Autori
Racané, Livio ; Cindrić, Maja ; Perin, Nataša ; Roškarić, Petra ; Starčević, Kristina ; Mašek, Tomislav ; Maurić, Maja ; Dogan, Jasna ; Karminski-Zamola, Grace

Izvornik
Croatica chemica acta (0011-1643) 90 (2017), 2; 187-195

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amidines, benzimidazoles, benzothiazoles, antioxidative activity in vitro

Sažetak
Herein we present the synthesis of versatile amidino substituted benzothiazole 3-10 and benzimidazole 12-19 derivatives substituted with the variable number of hydroxy and methoxy groups. Furthermore, the synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS and FRAP. The obtained results indicated that the variable number of hydroxy groups together with the type of the amidino substituent strongly influenced the antioxidative activity and reducing power of tested compounds. The most promising antioxidative activity showed trihydroxy substituted compounds 6, 10, 15 and 19. In general, it was noticed that unsubstituted amidino group induced the more pronounced activity in comparison to derivatives bearing 2-imidazolinyl group.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Veterinarska medicina

Napomena
Koautorica Roškarić Petra ne posjeduje matični broj



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )
HRZZ-IP-2014-09-8992 - Nutritivna modulacija metabolizma dokozaheksaenske kiseline kod dijabetičke dislipidemije

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)