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Pregled bibliografske jedinice broj: 880459

Dihydropyridine Derivatives as Cell Growth Modulators In Vitro


Bruvere, Imanta; Bisenieks, Egils; Poikans, Janis; Uldrikis, Janis; Plotniece, Aiva; Pajuste, Karlis; Rucins, Martins; Vigante, Brigita; Kalme, Zenta; Gosteva, Marina et al.
Dihydropyridine Derivatives as Cell Growth Modulators In Vitro // Oxidative Medicine and Cellular Longevity, 2017 (2017), 4069839-1 doi:10.1155/2017/4069839 (međunarodna recenzija, članak, znanstveni)


Naslov
Dihydropyridine Derivatives as Cell Growth Modulators In Vitro

Autori
Bruvere, Imanta ; Bisenieks, Egils ; Poikans, Janis ; Uldrikis, Janis ; Plotniece, Aiva ; Pajuste, Karlis ; Rucins, Martins ; Vigante, Brigita ; Kalme, Zenta ; Gosteva, Marina ; Domracheva, Ilona ; Velena, Astrida ; Vukovic, Tea ; Milkovic, Lidija ; Duburs, Gunars ; Zarkovic, Neven.

Izvornik
Oxidative Medicine and Cellular Longevity (1942-0900) 2017 (2017); 4069839-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dihydropyridine derivatives ; cell growth ; antiradical activity

Sažetak
The effects of eleven 1, 4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) antioxidant diludine ; (2) derivatives with pyridinium moieties at position 4 of the 1, 4-DHP ring ; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1, 4-DHP ring. Diludine and DHPs of group 3 exerted antiradical activities, unlike compounds of group 2. However, novel DHPs had cell type and concentration dependent effects on 3H-thymidine incorporation, while diludine did not. Hence, IB-32 (group 2) suppressed the growth of HOS and HeLa, enhancing growth of L929 cells, while K-2-11 (group 3) enhanced growth of every cell line tested, even in the presence of doxorubicin. Therefore, growth regulating and antiradical activity principles of novel DHPs should be further studied to find if DHPs of group 2 could selectively suppress cancer growth and if those of group 3 promote wound healing.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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