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Pregled bibliografske jedinice broj: 880341

Ataxia telangiectasia and juvenile idiopathic arthritis


Pasini, Agneza Marija; Gagro, Alenka; Roić, Goran; Vrdoljak, Ozren; Lujić, Lucija; Žutelija Fattorini, Matija
Ataxia telangiectasia and juvenile idiopathic arthritis // Pediatrics, 139 (2017), 2; e1-e4 doi:10.1542/peds.2016-1279 (međunarodna recenzija, kratko priopcenje, znanstveni)


CROSBI ID: 880341 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ataxia telangiectasia and juvenile idiopathic arthritis

Autori
Pasini, Agneza Marija ; Gagro, Alenka ; Roić, Goran ; Vrdoljak, Ozren ; Lujić, Lucija ; Žutelija Fattorini, Matija

Izvornik
Pediatrics (0031-4005) 139 (2017), 2; E1-e4

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
ataxia telangiectasia ; juvenile idiopathic arthritis

Sažetak
We report, to the best of our knowledge, the first case of a child with typical ataxia telangiectasia (A-T) who developed juvenile idiopathic arthritis (JIA). The patient was a 15-year-old boy with A-T who presented with noninfectious polyarthritis. A- T is a rare, autosomal recessive disorder characterized by cerebellar atrophy, oculocutaneous telangiectasia, immunodeficiency, radiosensitivity, and predisposition to cancer. The gene responsible for A-T is the A-T mutated (ATM) gene. Clinical manifestations of the disorder are the result of lacking ATM protein, which is involved in DNA repair, apoptosis, various checkpoints in the cell cycle, gene regulation, translation, initiation, and telomere maintenance. There are a few articles that describe deficiency of the DNA repair enzyme, ATM, in rheumatoid arthritis, but the connection between the absence of ATM protein and JIA has not been presented or studied yet. JIA is a heterogeneous group of diseases characterized by arthritis of unknown origin with onset before the age of 16 years. It is the most common childhood chronic rheumatic disease and causes significant disability. Because immunodeficiency can be part of A-T, infectious arthritis can occur, but chronic autoimmune arthritis in these patients is rare. We report a rare case of a 15-year-old boy with A-T and JIA. This case shows a possible relationship between altered function of ATM protein and the pathogenesis of JIA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta

Profili:

Avatar Url Alenka Gagro (autor)

Avatar Url Lucija Lujić (autor)

Avatar Url Goran Roić (autor)

Citiraj ovu publikaciju

Pasini, Agneza Marija; Gagro, Alenka; Roić, Goran; Vrdoljak, Ozren; Lujić, Lucija; Žutelija Fattorini, Matija
Ataxia telangiectasia and juvenile idiopathic arthritis // Pediatrics, 139 (2017), 2; e1-e4 doi:10.1542/peds.2016-1279 (međunarodna recenzija, kratko priopcenje, znanstveni)
Pasini, A., Gagro, A., Roić, G., Vrdoljak, O., Lujić, L. & Žutelija Fattorini, M. (2017) Ataxia telangiectasia and juvenile idiopathic arthritis. Pediatrics, 139 (2), e1-e4 doi:10.1542/peds.2016-1279.
@article{article, year = {2017}, pages = {e1-e4}, DOI = {10.1542/peds.2016-1279}, keywords = {ataxia telangiectasia, juvenile idiopathic arthritis}, journal = {Pediatrics}, doi = {10.1542/peds.2016-1279}, volume = {139}, number = {2}, issn = {0031-4005}, title = {Ataxia telangiectasia and juvenile idiopathic arthritis}, keyword = {ataxia telangiectasia, juvenile idiopathic arthritis} }
@article{article, year = {2017}, pages = {e1-e4}, DOI = {10.1542/peds.2016-1279}, keywords = {ataxia telangiectasia, juvenile idiopathic arthritis}, journal = {Pediatrics}, doi = {10.1542/peds.2016-1279}, volume = {139}, number = {2}, issn = {0031-4005}, title = {Ataxia telangiectasia and juvenile idiopathic arthritis}, keyword = {ataxia telangiectasia, juvenile idiopathic arthritis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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