engleski

Modern Therapeutic Approach To Alopecias

Majority of population has experienced in certain time of their life some type of hair loss. It is often cause of a great concern to the patient for cosmetic and psychological reasons. Here we present available therapeutic options for alopecia androgenetica (AGA) and alopecia areata (AA), the most common types of noncicatricial alopecias and also for folliculitis decalvans (FD), one of the most challenging causes of cicatricial alopecia. AGA is an androgen-dependent hair loss which affects roughly 50% of men and perhaps as many women older than 40 years. Topical minoxidil in concentration of 2% and 5% and finasteride are FDA-approved current therapies for androgenetic alopecia in men, whereas 2% minoxidil solution, oral contraceptives and spironolacton are proposed for female patients. Other possible therapeutic options, still mostly under clinical trial phases, include 5-α-reductase inhibitors, androgen receptor antagonists, ATP- sensitive potassium channel openers, growth factors, antioxydants and botanical extracts. AA is autoimmune non-scarring hair loss which affects 0, 1-0, 2% general population. Because of its autoimmune etiopathogenesis, corticosteroids applied topically or intralesionally still remain the cornerstone of initial treatment. Other potential therapies include topical sensitizing agents, photochemotherapy, pulse corticosteroid therapy, antibiotics and biologics. FD presents as an expanding patches of alopecia with peripheral pustules on the scalp resulting with scar formation. Although exact etiopathogenesis is still unknown, in most cases Staphylococcus aureus can be isolated from the pustules. Treatment of this condition consists of systemic antibiotics, topical or intralesional corticosteroids, retinoids or, newly suggested, biologics. Nondrug alopecias therapies such as hair transplantation, low-level laser therapy (LLLT), follicular neogenesis or inductive cell therapy could be beneficial for different forms of hair loss.

modern ; approach ; alopecias

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