Ferrocene-containing mannosides as inhibitors of E. coli adhesion (CROSBI ID 648918)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Kovač, Veronika ; Moguš, Leo ; Petrović Peroković, Vesna ; Tomić, Srđanka, Barišić, Lidija
engleski
Ferrocene-containing mannosides as inhibitors of E. coli adhesion
Bacterial adhesion to host cell surfaces is the prerequisite for the initiation of the infectious diseases. Urinary tract infections are the prevalent inflammatory diseases mainly caused by uropathogenic E. coli (UPEC). E. coli adhesion to the bladder epithelium is mediated through recognition of the tissue-surface mannosylated proteins with bacterial lectin FimH. The inhibition of this recognition-dependent interaction has been recognized as a promising strategy for the development of an anti-adhesion therapy. The mannosides with either aryl- or elongated alkyl-functionalized aglycon portions have been shown to be potent inhibitors of FimH- mediated adhesion. Herein, we present the synthesis of new bioorganometallics 8 and 9 containing amide groups, butyl or pentyl spacer and phenylalanine as an extra aromatic unit. The biological actvity of new compounds against bacterial lectin FimH is tested with hemagglutination inhbition assay (HAI).
Ferrocene ; Mannoside ; Inhibitor ; Hemagglutination
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Podaci o prilogu
137-137.
2017.
objavljeno
Podaci o matičnoj publikaciji
25. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka
Đaković, Marijana ; Šantić, Ana
Zagreb: Hrvatsko kemijsko društvo
978-953-55232-7-7
Podaci o skupu
25. hrvatski skup kemičara i kemijskih inženjera
poster
19.04.2017-22.04.2017
Poreč, Hrvatska