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Pregled bibliografske jedinice broj: 879336

The Value of Preablative Stimulated Thyroglobulin for Predicting the Recurrent and Persistent Disease of Differentiated Thyroid Cancer


Wagenhofer, Vlado; Mihaljević, Ivan; Kralj, Tatjana; Vrdoljak, Dubravka; Šnajder, Darija
The Value of Preablative Stimulated Thyroglobulin for Predicting the Recurrent and Persistent Disease of Differentiated Thyroid Cancer // 9th International Congress of the Croatian Society of Nuclear Medicine
Rovinj, 2017. (poster, nije recenziran, sažetak, znanstveni)


Naslov
The Value of Preablative Stimulated Thyroglobulin for Predicting the Recurrent and Persistent Disease of Differentiated Thyroid Cancer

Autori
Wagenhofer, Vlado ; Mihaljević, Ivan ; Kralj, Tatjana ; Vrdoljak, Dubravka ; Šnajder, Darija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th International Congress of the Croatian Society of Nuclear Medicine / - Rovinj, 2017

Skup
9th International Congress of the Croatian Society of Nuclear Medicine

Mjesto i datum
Rovinj, Hrvatska, 04-07.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Thyroglobulin ; differentiated thyroid cancer

Sažetak
Objective: We investigated the clinical importance of stimulated serum thyroglobulin at the time of radioiodine treatment (preablative Tg) for predicting the recurrent and persistent disease of differentiated thyroid cancer (DTC). Methods: The study included 235 consecutive patients with DTC submitted to total thyroidectomy and radioiodine ablation between 2005 and 2015 at University Hospital Osijek. Patients with positive anti-Tg antibodies were excluded from the study. Cut-off value of preablative Tg level was set to equal or grater than 10 ng/ml to test predictive value of preablative Tg for recurrent disease. Results: Clinically persistent or recurrent disease was diagnosed in 34/235 patients (14, 4%). Preablative stimulated Tg was elevated (≥ 10) in 62 patients and clinical (structural) recurrence was observed in 29 of these patient. Positive predictive value (PPV) of preablative Tg was 46, 7%. Preablative Tg ≥ 10 ng/ml was measured in 29/34 patients with recurrence (sensitivity: 85%). Negative predictive value (NPV) was 97% when preablative Tg value was less than 10 ng/ml. Persistent disease was diagnosed just in 5 cases (3%). Conclusions: The stimulated Tg level measured before radioiodine ablation (preablative Tg) significantly increases risk of recurrence in patients with DTC if its value was ≥ 10 ng/ml. Preablative Tg is useful negative predictor of persistent and recurrent disease. Patients with preablative Tg value of less than 10 ng/ml had only 3% likelihood of persistent DTC. Patients with preablative Tg ≥ 10 ng/ml had 15, 6 times greater chance of recurrent disease than those with values < 10 ng/ml.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek