Ultrasmall iron oxide nanoparticles for positive contrast MR imaging: structural, colloidal and magnetic properties (CROSBI ID 648691)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Babić-Stojić, Branka ; Jokanović, V. ; Milivojević, D. ; Požek, M ; Jagličić, Z. ; Makovec, D. ; Jović Orsini, N. ; Marković, M. ; Arsikin, K. ; Paunović, V.
engleski
Ultrasmall iron oxide nanoparticles for positive contrast MR imaging: structural, colloidal and magnetic properties
Ultrasmall crystalline iron oxide nanoparticles (USPIO NPs), with majority of the particles less than 3 nm in size dispersed in an organic fluid, were synthesized by polyol method. ZFCFC bifurcation and ac susceptibility peaks reveal that the nanoparticles are superparamagnetic with a blocking temperature T_B ~ 10 K. Considerably reduced measured magnetic field dependent magnetization at T > T_B, compared to the calculated dependence for noninteracting superparamagnetic NPs with a log-normal distribution of particle sizes, can be well described by modifying this distribution with field dependent average magnetic particle diameter. NMR relaxivity measurements on water diluted nanoparticle dispersions at magnetic field 1.5 T gave longitudinal and transverse relaxivity values r_1 = 0.028 mmol-1 s-1 and r_2 = 0.050 mmol-1 s-1 which resulted in the relaxivity ratio, r_2/r_1 = 1.8. The USPIO NPs dispersions have shown the properties of positive T_1 MRI contrast agents: increasing MR signal intensity in the T_1 -weighted image with increasing iron concentration in a wide concentration range. Cytotoxicity studies revealed that the USPIO NPs dispersions did not exert any significant cytotoxic activity on the B16 mouse melanoma cells at Fe concentrations of 1 mmol and below.
MRI contrasts, nanoparticles, magnetic properties
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Podaci o prilogu
87-87.
2017.
objavljeno
Podaci o matičnoj publikaciji
Third regional roundtable: Refractory, process industry, nanotechnologies and nanomedicine ROSOV PINN 2017 Programme and The Book of Abstracts
Jokanović, Vukoman
Beograd: Vinča Institute of Nuclear Sciences, Belgrade, Serbia // Serbian Society for Nanotechnologies and Nanomedicine // Serbian Society for Refractory and Process Industry
978-86-921143-0-4
Podaci o skupu
Third regional roundtable: Refractory, process industry, nanotechnologies and nanomedicine Rosov pinn 2017
poster
01.06.2017-02.06.2017
Beograd, Srbija