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Pregled bibliografske jedinice broj: 878826

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection


Popović, Branka; Golemac, Mijo; Podlech, J; Železnjak, Jelena; Bilić-Zulle, Lidija; Lukić, Mijo; Čičin-Šain, Luka; Reddehase, M; Sparwasser, T; Krmpotić, Astrid; Jonjić, Stipan
IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection // Plos pathogens, 13 (2017), 4; e1006345-1 doi:10.1371/journal.ppat.1006345 (međunarodna recenzija, članak, znanstveni)


Naslov
IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection

Autori
Popović, Branka ; Golemac, Mijo ; Podlech, J ; Železnjak, Jelena ; Bilić-Zulle, Lidija ; Lukić, Mijo ; Čičin-Šain, Luka ; Reddehase, M ; Sparwasser, T ; Krmpotić, Astrid ; Jonjić, Stipan

Izvornik
Plos pathogens (1553-7366) 13 (2017), 4; E1006345-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Interleukin-33, mouse ; mouse cytomegalovirus ; ST2 protein, mouse ; T-lymphocytes, regulatory

Sažetak
Regulatory T (Treg) cells dampen an exaggerated immune response to viral infections in order to avoid immunopathology. Cytomegaloviruses (CMVs) are herpesviruses usually causing asymptomatic infection in immunocompetent hosts and induce strong cellular immunity which provides protection against CMV disease. It remains unclear how these persistent viruses manage to avoid induction of immunopathology not only during the acute infection but also during life-long persistence and virus reactivation. This may be due to numerous viral immunoevasion strategies used to specifically modulate immune responses but also induction of Treg cells by CMV infection. Here we demonstrate that liver Treg cells are strongly induced in mice infected with murine CMV (MCMV). The depletion of Treg cells results in severe hepatitis and liver damage without alterations in the virus load. Moreover, liver Treg cells show a high expression of ST2, a cellular receptor for tissue alarmin IL-33, which is strongly upregulated in the liver of infected mice. We demonstrated that IL-33 signaling is crucial for Treg cell accumulation after MCMV infection and ST2-deficient mice show a more pronounced liver pathology and higher mortality compared to infected control mice. These results illustrate the importance of IL-33 in the suppressive function of liver Treg cells during CMV infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Version 2.



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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