hrvatski

Primjena autolognog kondicioniranog seruma u nekirurškoj i kirurškoj parodontnoj terapiji

Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis in the individual at risk for disease. Therefore, the successful long- term management of this disease may require a treatment strategy that integrates therapies that address all of these components. Autologous conditioned serum (ACS) is a biological method based on exposure of blood leukocytes to glass spheres surfaces that elicits an accumulation of anti-inflammatory cytokines, including interleukin-1 receptor antagonist, and several growth factors. The main rationale for the use of ACS is to locally deliver patient’s own anti- inflammatory cytokines into treated sites, and especially to saturate IL-1 receptors with IL-1ra as much as possible. Considering the composition of ACS and pathogenesis of periodontitis it is hypothesized that local application of ACS could contribute to better outcomes of non- surgical and surgical periodontal therapy. This presentation discusses the potential ways of ACS’s delivery in a course of periodontal therapy. Preliminary clinical results indicate that ACS could be a beneficial adjunct in the non-surgical treatment of severe generalized periodontitis. Further research in this field would also facilitate fabrication of individualized treatment for periodontal disease targeting inflammatory host response.

autologni kondicionirani serum ; parodontitis ; inicijalna terapija

nije evidentirano

engleski

Application of autologous conditioned serum in non-surgical and surgical periodontal therapy

Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis in the individual at risk for disease. Therefore, the successful long- term management of this disease may require a treatment strategy that integrates therapies that address all of these components. Autologous conditioned serum (ACS) is a biological method based on exposure of blood leukocytes to glass spheres surfaces that elicits an accumulation of anti-inflammatory cytokines, including interleukin-1 receptor antagonist, and several growth factors. The main rationale for the use of ACS is to locally deliver patient’s own anti- inflammatory cytokines into treated sites, and especially to saturate IL-1 receptors with IL-1ra as much as possible. Considering the composition of ACS and pathogenesis of periodontitis it is hypothesized that local application of ACS could contribute to better outcomes of non- surgical and surgical periodontal therapy. This presentation discusses the potential ways of ACS’s delivery in a course of periodontal therapy. Preliminary clinical results indicate that ACS could be a beneficial adjunct in the non-surgical treatment of severe generalized periodontitis. Further research in this field would also facilitate fabrication of individualized treatment for periodontal disease targeting inflammatory host response.

autologous conditioned serum ; periodontitis ; nonsurgical periodontal therapy

nije evidentirano