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Pregled bibliografske jedinice broj: 878472

Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration


Herrera-Molina, Rodrigo; Mlinac Jerković, Kristina; Ilić, Katarina; Stöber, Franziska; Vemula, Sampath Kumar; Sandoval, Mauricio; Jovanov Milošević, Nataša; Šimić, Goran; Smalla, Karl-Heinz; Goldschmidt, Jürgen et al.
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration // Scientific Reports, 7 (2017), 1; 7273-1 doi:10.1038/s41598-017-07839-9 (međunarodna recenzija, članak, znanstveni)


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Naslov
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration

Autori
Herrera-Molina, Rodrigo ; Mlinac Jerković, Kristina ; Ilić, Katarina ; Stöber, Franziska ; Vemula, Sampath Kumar ; Sandoval, Mauricio ; Jovanov Milošević, Nataša ; Šimić, Goran ; Smalla, Karl-Heinz ; Goldschmidt, Jürgen ; Kalanj Bognar, Svjetlana ; Montag, Dirk

Izvornik
Scientific Reports (2045-2322) 7 (2017), 1; 7273-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
neuroplastin ; PMCA ; cognition mechanisms ; glutamatergic neurons, calcium homeostasis ; learning impairment ; memory deficits ; synaptopathy

Sažetak
The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca2+ ATPases (PMCAs), an essential regulator of the intracellular Ca2+ concentration ([iCa2+]) and neuronal activity. We show abundant expression and conserved cellular and molecular features of Np in glutamatergic neurons in human hippocampal- cortical pathways as characterized for the rodent brain. In Nptnlox/loxEmx1Cre mice, glutamatergic neuron-selective Np ablation resulted in behavioral deficits indicating hippocampal, striatal, and sensorimotor dysfunction paralleled by highly altered activities in hippocampal CA1 area, sensorimotor cortex layers I-III/IV, and the striatal sensorimotor domain detected by single-photon emission computed tomography. Altered hippocampal and cortical activities correlated with reduction of distinct PMCA paralogs in Nptnlox/loxEmx1Cre mice and increased [iCa2+] in cultured mutant neurons. Human and rodent Np enhanced the post- transcriptional expression of and co-localized with PMCA paralogs in the plasma membrane of transfected cells. Our results indicate Np as essential for PMCA expression in glutamatergic neurons allowing proper [iCa2+] regulation and normal circuit activity. Neuron-type-specific Np ablation empowers the investigation of circuit-coded learning and memory and identification of causal mechanisms leading to cognitive deterioration.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-09-2014-9730

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Herrera-Molina, Rodrigo; Mlinac Jerković, Kristina; Ilić, Katarina; Stöber, Franziska; Vemula, Sampath Kumar; Sandoval, Mauricio; Jovanov Milošević, Nataša; Šimić, Goran; Smalla, Karl-Heinz; Goldschmidt, Jürgen et al.
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration // Scientific Reports, 7 (2017), 1; 7273-1 doi:10.1038/s41598-017-07839-9 (međunarodna recenzija, članak, znanstveni)
Herrera-Molina, R., Mlinac Jerković, K., Ilić, K., Stöber, F., Vemula, S., Sandoval, M., Jovanov Milošević, N., Šimić, G., Smalla, K. & Goldschmidt, J. (2017) Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration. Scientific Reports, 7 (1), 7273-1 doi:10.1038/s41598-017-07839-9.
@article{article, year = {2017}, pages = {7273-1-7273-13}, DOI = {10.1038/s41598-017-07839-9}, keywords = {neuroplastin, PMCA, cognition mechanisms, glutamatergic neurons, calcium homeostasis, learning impairment, memory deficits, synaptopathy}, journal = {Scientific Reports}, doi = {10.1038/s41598-017-07839-9}, volume = {7}, number = {1}, issn = {2045-2322}, title = {Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration}, keyword = {neuroplastin, PMCA, cognition mechanisms, glutamatergic neurons, calcium homeostasis, learning impairment, memory deficits, synaptopathy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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