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Therapeutic Use of Monoclonal Antibodies in Psoriasis-Immunological Principles and Immune- Based Adverse Effects

The introduction of monoclonal antibodies has provided a promising option for both short- and long- term treatment of different dermatologic diseases, and their use is continously increasing. However, because of the growing diversity and complexity of their individual action, there is also an inevitable increasing list of immune-based and non-immune adverse effects. The physician should be very familiar with the principles of effects of biological agents, to avoid unnecessary risks. The basic information about immunological principles of therapeutic effects of monoclonal antibodies will be given, with particular accent on some main groups of new and approved biological agents in psoriasis. Immune-based adverse effects will be mentioned. General and specific considerations about use of biologic therapy in psoriasis will be discussed, which could help dermatologists in planning and prescribing biologic therapy. This communication reviews some basic immunological principles and immune- based adverse effects of biological therapy in psoriasis, including considerations for their use.

monoclonal, antibodies, psoriasis

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